A Novel Paradigm in Dentistry- Stem Cell Therapy: A Comprehensive Review

Authors

  • Dr. Shivangi Singh Senior Lecturer, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr.Nidhi Puri Associate Professor, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr. Upasana Sethi Ahuja Head of Department and Professor, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr. Manu Dhillon Professor, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr. Akshay Rathore Reader, Professor, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr. Seema Ahuja Senior Lecturer, Department of Oral Medicine and Radiology. I.T.S Dental College, Muradnagar, Ghaziabad, Uttar Pradesh, India Author
  • Dr. Nidhi Puri Associate Professor, Department of Oral Medicine and Radiology, I.T.S Dental College, Muradnagar, Ghaziabad, UP. Author

DOI:

https://doi.org/10.61841/cc4xfj89

Keywords:

Regenerative dentistry, Adult stem cells, Mesenchymal stem cells, stem cell banks

Abstract

Stem cells have the capability to influence the millions of lives by offering unparalleled possibilities for emerging new medical therapies for crippling and terminal diseases and a new way to explore essentials of biology, making a template for cell-based therapies. These unique cells have remarkable potential of endless self-renewal and differentiation into numerous cell types. Every new cell in turn can either remain as a stem cell or get differentiated to emerge into a new cell with more specialized function e.g a muscle cell, brain cell or red blood cell. Recent literature has targeted the use of several stem cells extracted extraoral and intra orally that can be applied in regenerative dentistry; posing numerous potential therapeutic applications. This leads us to the cutting edge of stem cell research as it has numerous applications in dentistry. An innovative perspective for the application of stem cells in multifaceted dentistry requires detailed planning and comprehensive research work. It is the need of the hour to shift from corrective dentistry to preventive and regenerative dentistry. Thus, this review emphasizes on characteristic properties, challenges and current research, along with new avenues and prospects of stem cells in dentistry and in management of oral mucosal lesions.

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References

1. Nadig RR. Stem cell therapy – Hype or hope? A review. J Conserv Dent. 2009; 12(4): 131–138

2. Wobus AM, Boheler KR. Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy. Physiol Rev. 2005;85(2):635-78.

3. Ramalho-Santos M, Willenbring H. On the origin of the term ‘stem cell’. Cell Stem Cell 2007; 1: 35–38.

4. Fortier LA. Stem cells: classifications, controversies, and clinical applications. Vet Surg. 2005;34(5):415-23.

5. Ann A. Kiessling& Scott C. Anderson. Human embryonic stem cells - 2ndedn. New York:Elsievier;2010.p.26-8.

6. PM Sunil, R Manikandhan, MS Muthu, and S Abraham. Stem cell therapy in oral and maxillofacial region: An overview. J Oral MaxillofacPathol. 2012; 16(1): 58–63.

7. Loebinger MR, Aguilar S, Janes SM. Therapeutic potential of stem cells in lung disease: progress and pitfalls. ClinSci (Lond). 2008 ;114(2):99-108.

8. Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry – Part I: Stem cell sources. J Prosthodont Res. 2012;56(3):151-65.

9. Hanna J, Hubel A. Preservation of stem cells. Organogenesis. 2009;5(3):134-7.

10. Sunil PM, Manikandan R, Muthumurugan, Yoithapprabhunath TR, Sivakumar M. Harvesting dental stem cells - Overview. J Pharm Bioallied Sci. 2015;7(Suppl 2): S384-6

11. Bluteau G, Luder HU, De Bari C, Mitsiadis TA. Stem cells for tooth engineering. European Cells and Materials 2008;16: 1-9

12. Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry--Part II: Clinical applications. J Prosthodont Res. 2012 ;56(4):229-48.

13. Hu MS, Borrelli MR, Lorenz HP, Longaker MT, Wan DC. Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential. Stem Cells Int. 2018; 2018:6901983.

14. Ding G, Wang W, Liu Y, Zhang C, Wang S. Mesenchymal stem cell transplantation: a potential therapy for oral lichen planus. Med Hypotheses. 2011;76(3):322-4.

15. SarrafC.Emerging themes of cancer stem cells : Editorial –overview. Cell Profile 2005;38:343-5.

16. Holyoake TL et al. Premetive quiescent leukemia spontaneously initiate factor dependent growth in vitro in association with up- regulation of expression of interleukin-3.Blood 2001;97:720-8.

17. XinL,LawsonDA,WitteON.The Sca-1cell surface marker enriches for a prostate –regenerating cell subpopulation that can initiate prostate tumorigenesis. ProcNatlAcadSci USA 2005;102:6942-7.

18. Hirschmann-Jax C et al. A distinct side population of cells with high drug efflux capacity in human tumor cells. ProcNatlAcadSci USA 2005;01:14228-33.

19. Sherley JL. Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture.Stem cells 2002;20:516-72.

20. Gonçalves GAR, PaivaRMA.Gene therapy: advances, challenges and perspectives.Einstein (Sao Paulo). 2017 ;15(3):369-375

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Published

31.10.2020

How to Cite

Singh , S., Puri , N., Ahuja , U. S., Dhillon, M., Rathore , A., Ahuja , S., & Puri, N. (2020). A Novel Paradigm in Dentistry- Stem Cell Therapy: A Comprehensive Review. International Journal of Psychosocial Rehabilitation, 24(8), 12467-12476. https://doi.org/10.61841/cc4xfj89