Effect of Prenatal Ketamine Exposure on GFAP Marker Expression in Mice Prefrontal Cortex Mice Prefrontal Cortex
DOI:
https://doi.org/10.61841/xb27dc92Keywords:
Prenatal Ketamine, GFAP marker, Prefrontal cortex,, Fluorescent ImmunohistochemistryAbstract
Ketamine, N-Methyl-D-Aspartate receptor antagonist agent, is widely used clinically for anesthesia, particularly in the developing countries. About 2% of pregnant women in the United States required surgeries because of the problems related to the pregnancy itself or due to other medical conditions, and ketamine regarded the first choice of anesthesia. This percentage is increasing, relatively because of laparoscopic procedures and fetal surgery.
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[1] Abdallah Chadi G., Henk M. De Feyter, Lynnette A. Averill, Lihong Jiang, Christopher L. Averill, Golam
M. I. Chowdhury, Prerana Purohit, Robin A. de Graaf, Irina Esterlis, Christoph Juchem, Brian P. Pittman, John H. Krystal, Douglas L. Rothman, Gerard Sanacora and Graeme F. Mason (2018): The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 43:2154–2160.
[2] Abou-Madi N. (2006): Anesthesia and Analgesia of Small Mammals: Recent Advances in Veterinary Anesthesia and Analgesia: Companion Animals. In: Gleed RD, Ludders JW, eds. Ithaca NY: International Veterinary Information Service (www.ivis.org). pp. 1-9.
[3] Caso J. R., J. M. Pradillo, O. Hurtado, P. Lorenzo, M. A. Moro, and I. Lizasoain, (2007): “Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke,” Circulation, vol. 115, no. 12, pp. 1599–1608.
[4] Chamoun R., D. Suki, S. P. Gopinath, J. C. Goodman, and C. Robertson, (2010): “Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury,” Journal of Neurosurgery, vol. 113, no. 3, pp. 564–570.
[5] Cheek, T. G. & Baird, E. (2009): Anesthesia for non-obstetric surgery: maternal and fetal considerations. Clinical Obstetrics and Gynecology 52, 535–545.
[6] Craven, R. Ketamine (2007). Anaesthesia 62 (S1), 48–53.
[7] Daneman, Richard (2012): The blood-brain barrier in health and disease. Annals of Neurology 72(5):648- 72.
[8] Ellingson, A., Haram, K., and Solheim, E. (1977). Transplacental passage of ketamine after intravenous administration. Acta. Anaesthesia. Scand. 21, 41–44.
[9] Ferreira T. and Rasband W.: The Image J User Guide – V; 1.46. October 2012 .
[10] Hahn, N., Eisen, R.J., Eisen, L. & Lane, R.S. (2005). Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions. Lab. animal, 34(2), p. 48-52 .
[11] Luissint A.C., Federici C., Guillonneau F., Chretien F., Camoin L., Glacial F. et al. (2012). Guanine nucleotide-binding protein Galphai2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells. Journal of Cerebral Blood Flow Metabolism. 32, 860–873.
[12] Musk, G. C., Netto, J. D., Maker, G. L., and Trengove, R. D. (2012). Transplacental transfer of medetomidine and ketamine in pregnant ewes. Lab. Animals. 46, 46–50 .
[13] Nicole O., C. Ali, F. Docagne et al. (2001): “Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway,” The Journal of Neuroscience, vol. 21, no. 9, pp. 3024–3033.
[14] Okada S., M. Nakamura, H. Katoh et al., (2006): “Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury,” Nature Medicine, vol. 12, no. 7, pp. 829–834 .
[15] Palmer, A. M., Marion D. W., Botscheller M.L., Swedlow P.E., Styren S.D., and DeKosky S.T. (1993): Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. Journal of Neurochemistry. 61, 2015–2024.
[16] Sofroniew M.V., & Vinters, H.V. (2010). Astrocytes: biology and pathology. Acta neuropathologica,
119(1), 7-35.
[17] Taylor C.R., Shi S.R., Barr N.J., and Wu N. (2006): Techniques of immunohistochemistry. Principles, pitfalls and standardization. Diagnostic Immunohistochemistry 2: 3-44.
[18] Thompson R. E., A. Lake, P. Kenny et al., (2017): “Different mixed astrocyte populations derived from embryonic stem cells have variable neuronal growth support capacities,” Stem Cells and Development, vol. 26, no. 22, pp. 1597–1611.
[19] Vasudevan A., Long J.E., Crandall J.E., Rubenstein J.L., and Bhide P.G. (2008): Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nature. Neuroscience. 11, 429–439.
[20] Vijayan M. and P. H. Reddy (2016): “Stroke, vascular dementia, and Alzheimer’s disease: molecular links,” Journal of Alzheimer's Disease, vol. 54, no. 2, pp. 427–443.
[21] Zheng, H. et al. (2013): Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology 118, 516–526.
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