TURMERIC AND ITS PHARMACOLOGICAL PROPERTIES - A REVIEW
DOI:
https://doi.org/10.61841/xyhxn532Keywords:
Anti viral, Anti inflammatory, Anticancer, Curcumin, Curcumin longa, TurmericAbstract
Turmeric is a flowering plant, Curcuma longa of the ginger family, Zingiberaceae, the roots of which are used in cooking. The plant is a perennial, rhizomatous, herbaceous plant local to the Indian subcontinent and Southeast Asia that calls for temperatures between 20 and 30 °C (68 and 86 °F) and a large amount of annual rainfall to thrive. Plants are gathered each year for their rhizomes, a few for propagation in the following season and some for consumption. This is a review-based study on the topic of turmeric over viral diseases. Articles based on turmeric were referred to completely, which were taken from “PubMed,” “Google Scholar,” and PMC. Around 20-25 articles were referred. Other articles that have done a study on the medicinal and pharmacological properties of turmeric are also compared. Hence turmeric has a wide range of biological activities that can be used for the preparation of various formulations for the treatment of various conditions.
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References
1. Balachandran K, Stebbing J. Turmeric: a spice for life? [Internet]. Vol. 17, The Lancet Oncology. 2016. p.
1639. Available from: http://dx.doi.org/10.1016/s1470-2045(16)30587-3
2. Ammon H, Anazodo M, Safayhi H, Dhawan B, Srimal R. Curcumin: A Potent Inhibitor of Leukotriene
B4Formation in Rat Peritoneal Polymorphonuclear Neutrophils (PMNL) [Internet]. Vol. 58, Planta
Medica. 1992. p. 226–226. Available from: http://dx.doi.org/10.1055/s-2006-961438
3. Nair KP. Turmeric: Origin and History [Internet]. Turmeric (Curcuma longa L.) and Ginger (Zingiber
officinale Rosc.) - World’s Invaluable Medicinal Spices. 2019. p. 1–6. Available from:
http://dx.doi.org/10.1007/978-3-030-29189-1_1
4. Nair KP. The Botany of Turmeric [Internet]. Turmeric (Curcuma longa L.) and Ginger (Zingiber
officinale Rosc.) - World’s Invaluable Medicinal Spices. 2019. p. 7–35. Available from:
http://dx.doi.org/10.1007/978-3-030-29189-1_2
5. Krishnaswamy K. Turmeric: The Salt of the Orient is the Spice of Life. Allied Publishers; 2009. 264 p.
6. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent,
against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
[Internet]. Vol. 41, The International Journal of Biochemistry & Cell Biology. 2009. p. 40–59. Available
from: http://dx.doi.org/10.1016/j.biocel.2008.06.010
7. Omosa LK, Midiwo JO, Kuete V. Curcuma longa [Internet]. Medicinal Spices and Vegetables from
Africa. 2017. p. 425–35. Available from: http://dx.doi.org/10.1016/b978-0-12-809286-6.00019-4
8. Majeed M, Badmaev V, Murray F. Turmeric and the Healing Curcuminoids. McGraw Hill Professional;
1999. 48 p.
9. Nair KP. Turmeric in Ayurveda [Internet]. Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale
Rosc.) - World’s Invaluable Medicinal Spices. 2019. p. 235–43. Available from:
http://dx.doi.org/10.1007/978-3-030-29189-1_14
10. Taylor G. Turmeric: Nutritional Properties, Uses and Potential Benefits. 2015. 140 p.
11. Nair KP. Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale Rosc.) - World’s Invaluable
Medicinal Spices: The Agronomy and Economy of Turmeric and Ginger. Springer Nature; 2019. 568 p.
12. Nawab A, Tang S, Li G, An L, Wu J, Liu W, et al. Dietary curcumin supplementation effects on blood
immunological profile and liver enzymatic activity of laying hens after exposure to high temperature
conditions. J Therm Biol. 2020 May;90:102573.
13. Fathima F, Preetha P. EVALUATION OF THYROID FUNCTION TEST IN OBESE PATIENTS
[Internet]. Vol. 9, Asian Journal of Pharmaceutical and Clinical Research. 2016. p. 353. Available from:
http://dx.doi.org/10.22159/ajpcr.2016.v9s3.12959
14. Samuel AR, Devi MG. Geographical distribution and occurrence of Endemic Goitre [Internet]. Vol. 8,
Research Journal of Pharmacy and Technology. 2015. p. 973. Available from:
http://dx.doi.org/10.5958/0974-360x.2015.00162.6
15. Harsha L, Priya J, Shah KK, Reshmi B. Systemic Approach to Management of Neonatal Jaundice and
Prevention of Kernicterus [Internet]. Vol. 8, Research Journal of Pharmacy and Technology. 2015. p.
1087. Available from: http://dx.doi.org/10.5958/0974-360x.2015.00189.4
16. Choudhari S, Jothipriya MA. Non-alcoholic fatty liver disease [Internet]. Vol. 9, Research Journal of
Pharmacy and Technology. 2016. p. 1782. Available from: http://dx.doi.org/10.5958/0974-
360x.2016.00360.7
17. Swathy S, Gowri Sethu V. Acupuncture and lower back pain [Internet]. Vol. 8, Research Journal of
Pharmacy and Technology. 2015. p. 991. Available from: http://dx.doi.org/10.5958/0974-
360x.2015.00165.1
18. Renuka S, Sethu G. Regeneration after Myocardial Infarction [Internet]. Vol. 8, Research Journal of
Pharmacy and Technology. 2015. p. 738. Available from: http://dx.doi.org/10.5958/0974-
360x.2015.00117.1
19. Agarwal S, Mishra R, Gupta AK, Gupta A. Turmeric: isolation and synthesis of important biological
molecules [Internet]. Synthesis of Medicinal Agents from Plants. 2018. p. 105–25. Available from:
http://dx.doi.org/10.1016/b978-0-08-102071-5.00005-2
20. Ara�jo MCP, Antunes LMG, Takahashi CS. Protective effect of thiourea, a hydroxyl-radical scavenger,
on curcumin-induced chromosomal aberrations in an in vitro mammalian cell system [Internet]. Vol. 21,
Teratogenesis, Carcinogenesis, and Mutagenesis. 2001. p. 175–80. Available from: 3.0.co;2-
v">http://dx.doi.org/10.1002/1520-6866(2001)21:2<175::aid-tcm6>3.0.co;2-v
21. Mizushina Y, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, et al. Study on the
Molecular Structure and Bio-Activity (DNA Polymerase Inhibitory Activity, Anti-Inflammatory Activity and Anti-Oxidant Activity) Relationship of Curcumin Derivatives [Internet]. Vol. 3, Current Bioactive
Compounds. 2007. p. 171–7. Available from: http://dx.doi.org/10.2174/157340707781695488
22. Ali M, Bagati A, Gupta J. ChemInform Abstract: Synthesis and Antiinflammatory Activity of Some
Curcumin Analogues [Internet]. Vol. 26, ChemInform. 2010. p. no – no. Available from:
http://dx.doi.org/10.1002/chin.199552195
23. Kuttan R, Bhanumathy P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma
longa) [Internet]. Vol. 29, Cancer Letters. 1985. p. 197–202. Available from:
http://dx.doi.org/10.1016/0304-3835(85)90159-4
24. Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin-free turmeric exhibits anti-inflammatory and
anticancer activities: Identification of novel components of turmeric [Internet]. Vol. 57, Molecular
Nutrition & Food Research. 2013. p. 1529–42. Available from: http://dx.doi.org/10.1002/mnfr.201200838
25. Gul P, Bakht J. Antimicrobial activity of turmeric extract and its potential use in food industry [Internet].
Vol. 52, Journal of Food Science and Technology. 2015. p. 2272–9. Available from:
http://dx.doi.org/10.1007/s13197-013-1195-4
26. Juglal S, Govinden R, Odhav B. Spice Oils for the Control of Co-Occurring Mycotoxin-Producing Fungi
[Internet]. Vol. 65, Journal of Food Protection. 2002. p. 683–7. Available from:
http://dx.doi.org/10.4315/0362-028x-65.4.683
27. Schaefer EW, Pavoni JMF, Luchese CL, Faccin DJL, Tessaro IC. Influence of turmeric incorporation on
physicochemical, antimicrobial and mechanical properties of the cornstarch and chitosan films. Int J Biol
Macromol. 2020 Apr 1;148:342–50.
28. Oghenejobo M. Antibacterial Evaluation, Phytochemical Screening and Ascorbic Acid Assay of Turmeric
(Curcuma longa) [Internet]. Vol. 4, MOJ Bioequivalence & Bioavailability. 2017. Available from:
http://dx.doi.org/10.15406/mojbb.2017.04.00063
29. Mahour SS, Nema SP, Chhabra D, Bhardwaz A, Karmore SK. Antibacterial Property of Hot and Cold
Extracted Turmeric Extract: An In-Vitro Study [Internet]. Vol. 7, International Journal of Current
Microbiology and Applied Sciences. 2018. p. 3147–51. Available from:
http://dx.doi.org/10.20546/ijcmas.2018.710.364
30. Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, et al. Turmeric
curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut. 2014
Jul;63(7):1137–49.
31. Jassim SAA, Naji MA. Novel antiviral agents: a medicinal plant perspective. J Appl Microbiol.
2003;95(3):412–27.
32. Tomei L, Altamura S, Paonessa G, De Francesco R, Migliaccio G. HCV antiviral resistance: the impact of
in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase. Antivir Chem
Chemother. 2005;16(4):225–45.
33. Lemoine M, Nayagam S, Thursz M. Viral hepatitis in resource-limited countries and access to antiviral
therapies: current and future challenges. Future Virol. 2013 Apr;8(4):371–80.
34. Clercq E de, de Clercq E, Herdewijn P. Strategies in the Design of Antiviral Drugs [Internet]. Drug
Discovery Handbook. 2005. p. 1135–90. Available from: http://dx.doi.org/10.1002/0471728780.ch25
35. Moghadamtousi SZ, Hajrezaei M, Kadir HA, Zandi K. Loranthus micranthusLinn.: Biological Activities
and Phytochemistry [Internet]. Vol. 2013, Evidence-Based Complementary and Alternative Medicine.
2013. p. 1–9. Available from: http://dx.doi.org/10.1155/2013/273712
36. Dairaku I, Han Y, Yanaka N, Kato N. Inhibitory effect of curcumin on IMP dehydrogenase, the target for
anticancer and antiviral chemotherapy agents. Biosci Biotechnol Biochem. 2010 Jan 7;74(1):185–7.
37. Kumar S, Narain U, Tripathi S, Misra K. Syntheses of Curcumin Bioconjugates and Study of Their
Antibacterial Activities against beta-Lactamase-Producing Microorganisms. Bioconjug Chem. 2001
Jul;12(4):464–9.
38. Kumar R, Bhattacharyya S, Singh S, Sarfraz A, Kumar D, Sengupta A, et al. STUDY OF INHIBITORY
EFFECT OF EXTRACT OF TURMERIC (CURCUMA LONGA) ON STAPHYLOCOCCUS AUREUS
[Internet]. Vol. 32, International Journal of Therapeutic Applications. 2016. p. 38–40. Available from:
http://dx.doi.org/10.20530/ijta_32_38-40
39. Thomas-Eapen NE. Turmeric: The Intriguing Yellow Spice With Medicinal Properties [Internet]. Vol. 5,
EXPLORE. 2009. p. 114–5. Available from: http://dx.doi.org/10.1016/j.explore.2008.12.008
40. Sharma OP. Antioxidant activity of curcumin and related compounds [Internet]. Vol. 25, Biochemical
Pharmacology. 1976. p. 1811–2. Available from: http://dx.doi.org/10.1016/0006-2952(76)90421-4
41. Parveen Z, Nawaz S, Siddique S, Shahzad K. Composition and Antimicrobial Activity of the Essential Oil
from Leaves of Curcuma longa L. Kasur Variety [Internet]. Vol. 75, Indian Journal of Pharmaceutical
Sciences. 2013. p. 117. Available from: http://dx.doi.org/10.4103/0250-474x.113544
42. Baheerati MM, Gayatri Devi R. Obesity in relation to Infertility [Internet]. Vol. 11, Research Journal of
Pharmacy and Technology. 2018. p. 3183. Available from: http://dx.doi.org/10.5958/0974-
360x.2018.00585.1
43. Dave PH, Preetha. Pathogenesis and Novel Drug for Treatment of Asthma-A Review [Internet]. Vol. 9,
Research Journal of Pharmacy and Technology. 2016. p. 1519. Available from:
http://dx.doi.org/10.5958/0974-360x.2016.00297.3
44. R GD, Sethu G. EVALUATION OF ADENOIDS BY ORONASAL AND NASAL SPIROMETRY
[Internet]. Vol. 11, Asian Journal of Pharmaceutical and Clinical Research. 2018. p. 272. Available from:
http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27365
45. Timothy CN, Gayatri Devi R, Jothi Priya A. Evaluation of Peak Expiratory Flow Rate (PEFR) in Pet
Owners [Internet]. Vol. 10, Indian Journal of Public Health Research & Development. 2019. p. 803.
Available from: http://dx.doi.org/10.5958/0976-5506.2019.01989.2
46. Shruthi M, Preetha S. Effect of Simple Tongue Exercises in Habitual Snorers [Internet]. Vol. 11, Research
Journal of Pharmacy and Technology. 2018. p. 3614. Available from: http://dx.doi.org/10.5958/0974-
360x.2018.00665.0
47. Rj I, R GD. Role of environmental factors on sleep patterns of different age groups [Internet]. Vol. 9,
Asian Journal of Pharmaceutical and Clinical Research. 2016. p. 124. Available from:
http://dx.doi.org/10.22159/ajpcr.2016.v9i6.13832
48. Iyer PK, Gayatri Devi R, Jothi Priya A. A Survey Study on Causes, Treatment and Prevention of
Onychocryptosis [Internet]. Vol. 10, Indian Journal of Public Health Research & Development. 2019. p.
807. Available from: http://dx.doi.org/10.5958/0976-5506.2019.01990.9
49. David, David, Jothi Priya A, Devi G. Physical Fitness among the Dental Physician, Dental
Undergraduates and Postgraduates Students [Internet]. Vol. 10, Indian Journal of Public Health Research
& Development. 2019. p. 223. Available from: http://dx.doi.org/10.5958/0976-5506.2019.02801.8
50. Abigail, Abigail, Priya J, Devi G. Evaluation of Muscular Endurance among Dentists [Internet]. Vol. 10,
Indian Journal of Public Health Research & Development. 2019. p. 258. Available from:
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