The Relationship between Functional Ovarian Cyst and Ovarian Reserve among Infertile Females

Authors

  • Mozhgan Modoodi Gynecologist, Tehran Azad University of Medical Sciences, Tehran, Iran Author
  • Maryam Zare Gynecologist, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Author
  • Roshan Nikbakht, Fertility, Infertilty and Perinatology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Author
  • Maryam Mirzaei Gynecologist, Jiroft University of Medical Science, Jiroft, Kerman, Iran. Author
  • Mahshid Bazrafkan Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Author
  • Mina Ataei Assistant Professor, Department of Obstetrics and Gynecology, Social Determinants of Health Research Center School of Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran Author

DOI:

https://doi.org/10.61841/edfrj962

Keywords:

Ovarian Reserve, Anti-Müllerian Hormone, Ovarian Physiological Cyst.

Abstract

 Introduction: Functional ovarian cyst is a common phenomenon in women. Ovarian reserve changes with increasing the age or under the effect of ovarian diseases. This age-related reduction in ovarian reserve, especially in women who have lower ovarian reserve due to ovarian diseases, can have a greater impact on the women's fertility. The present study was conducted to compare the ovarian reserve in the infertile women with and without a functional ovarian cyst by measuring the serum levels of the anti-Müllerian hormone. Materials and Methods: The present study is an analytical study conducted on 60 infertile women referred to the Infertility Research Center of Ahvaz Jundishapur University of Medical Sciences in 2011. Transvaginal sonography was first performed and based on the sonography, the patients were divided into two groups, including a case group (n = 30) with an ovarian cyst and a control group (n = 30) without a ovarian cyst. The blood samples were taken from all patients to measure the serum levels of the anti-Müllerian hormone and the samples were sent to a laboratory (Tohidi Laboratory). After 3 months, transvaginal sonography was re-performed on the patients with cysts to diagnose the cases of persistent cysts or other ovarian cysts. The ovarian reserve was compared between the two groups according to the mean serum levels of the anti-Müllerian hormone. The data were analyzed using SPSS version 17 software. The significance level was considered 0.05. Results: The mean age of the case and control groups was 28.66 and 29.16 years, respectively. Duration of the infertility and the number of people with primary or secondary infertility were not significantly different between the two groups. The mean serum levels of the anti-Müllerian hormone were 2.70 ng / ml in the case group and 2.55 ng / ml in the control group (P = 0.821). Conclusion: Based on the results, the rate of ovarian reserve in the infertile women with and without a physiological ovarian cyst is not different. Further studies with larger sample sizes are recommended to confirm the results of this study. 

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References

[1] Gelbaya TA, Potdar N, Jeve YB, Nardo LG. Definition and epidemiology of unexplained infertility. Obstet

Gynecol Surv. 2014; 69(2):109-15.

[2] Speroff Leon, Fritz marc A, et al. Clinical gynecologic endocrinology and infertility. Lippincott Williams &

Wilkins.8 th edition.2011.

[3] Kitajima M, Khan KN, Harada A, Taniguchi K, Inoue T, Kaneuchi M, et al. Association between ovarian

endometrioma and ovarian reserve. Frontiers in bioscience (Elite edition). 2018; 10: 92-102.

[4] Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy Ch, Englert Y. Stable serum levels of antiMüllerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum

Reprod. 2007; 22(7):1837-40.

[5] La Marka A, Sighinolfi G, Radi D, Argento C, Baraldi E, Artenisio AC, Stabile G, Volpe A. AntiMullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod

Update. 2010; 16(2):113-30.

[6] Van Houten EL, Themmen AP, Visser JA. Anti-Müllerian hormone (AMH): regulator and marker of

ovarian function. Ann Endocrinol. 2010 May; 71(3): 191-7.

[7] La Marca A, Broekmans FJ, Volpe A, Fauser BC, Macklon NS. Anti-Mullerian hormone (AMH): what do

we still need to know? Hum Reprod. 2009; 24(9): 2264-75.

[8] Yu M, Deng CY. Clinical applications of anti-Müllerian hormone in evaluating ovarian reserve functions.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009; 31(1):114-9.

[9] Padma Rekha Jirge. Poor ovarian reserve. J Hum Reprod Sci. 2016; 9(2): 63–69.

[10] Somigliana E, Marchese MA, Frattaruolo MP, Berlanda N, Fedele L, Vercellini P. Serum anti-mullerian

hormone in reproductive aged women with benign ovarian cysts. Eur J Obstet Gynecol Reprod Biol. 2014;

180:142-7.

[11] Salihoğlu KN, Dilbaz B, Cırık DA, Ozelci R, Ozkaya E, Mollamahmutoğlu L. Short-Term Impact of

Laparoscopic Cystectomy on Ovarian Reserve Tests in Bilateral and Unilateral Endometriotic and

Nonendometriotic Cysts. J Minim Invasive Gynecol. 2016; 23(5):719-25.

[12] Mohamed AA, Al-Hussaini TK, Fathalla MM, El Shamy TT, Abdelaal II, Amer SA. The impact of

excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. Am J Obstet

Gynecol. 2016; 215(2):169-76.

[13] Farghaly SA. Current diagnosis and management of ovarian cysts. Clin Exp Obstet Gynecol. 2014; 41(6):

609-12.

[14] Berek J, et al. Berek & Novak s gynecology. Lippincott Williams & wilkins.15th edition.2012.

[15] Greenlee RT, Kessel B, Williams CR, Riley TL, Ragard LR, Hartge P, Buys SS, Partridge EE, Reding DJ.

Prevalence, incidence, and natural history of simple ovarian cysts among women >55 years old in a large

cancer screening trial. Am J Obstet Gynecol. 2010; 202(4): 373.

[16] Glanc P1, Brofman N, Salem S, Kornecki A, Abrams J, Farine D. The prevalence of incidental simple

ovarian cysts >or= 3 cm detected by transvaginal sonography in early pregnancy. J Obstet Gynaecol Can.

2007; 29(6): 502-6.

[17] BMJ Publishing Group Limited 2011. http://bestpractice.bmj.com/best-practice/monograph/660/basics/

epidemiology.html.Last updated: Jul06, 2011.

[18] Chang HJ, Han SH, Lee JR, Jee BC, Lee BI, Suh CS, Kim SH. Impact of laparoscopic cystectomy on

ovarian reserve: serial changes of serum anti-Müllerian hormone levels. Fertil Steril. 2010; 94(1): 343-9.

[19] Legendre G, Catala L, Morinière C, Lacoeuille C, Boussion F, Sentilhes L, Descamps P. Relationship

between ovarian cysts and infertility: what surgery and when? Fertil Steril. 2014; 101(3):608-14.

[20] Keyhan S, Hughes C, Price T, Muasher S. An Update on Surgical versus Expectant Management of

Ovarian Endometriomas in Infertile Women. Biomed Res Int. 2015; 2015: 204792.

[21] Hu Y, Ye Y, Gong X, Ran F-f. Transient Neurologic Symptoms Following Spinal Anesthesia with

Bupivacaine and Ropivacaine. SN Comprehensive Clinical Medicine. 2019:1-6

[22] Somigliana E, Marchese MA, Frattaruolo MP, Berlanda N, Fedele L, Vercellini P. Serum anti-mullerian

hormone in reproductive aged women with benign ovarian cysts. Eur J Obstet Gynecol Reprod Biol. 2014;

180:142-7.

[23] Csokmay JM, Frattarelli JL. Basal ovarian cysts and clomiphene citrate ovulation induction cycles. Obstet

Gynecol. 2006; 107(6):1292-6.

[24] Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Bayasula B, Nakamura T, Manabe

S, Kikkawa F. The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality

and severity of endometriosis. Hum Reprod. 2011; 26(4): 904-10.

[25] Hwu YM, Wu FS, Li SH, Sun FJ, Lin MH, Lee RK. The impact of endometrioma and laparoscopic

cystectomy on serum anti-Müllerian hormone levels. Reprod Biol Endocrinol. 2011; 9:80.

[26] Yadollahi, P., Khalajinia, Z. and Khormaei, F., 2018. Cultural differences in perception of labor pain

without considering to painless technique. Journal of Advanced Pharmacy Education & Research, 8(S2),

pp.9–14.

[27] Khorasani Baghini, F., khosravani, M., Amiri, A.(2018) Evaluation of the effect of the provided training in

delivery preparation classes on awareness and attitude of pregnant mothers toward delivery type in Razi

Hospital of Saravan. Revista Latinoamericana de Hipertension, 13 (6), pp.534-537.

[28] Yadollahi, P., Taghizdeh, Z. and Ebadi, A., 2018. A comprehensive description of delivery pain using a

qualitative approach. Journal of Advanced Pharmacy Education & Research, 8(S2), pp.59–63.

[29] Fahimeh Khorasani Baghini, mahboobeh khosravani, Azadeh Amiri, Evaluation of the effect of the

provided training in delivery preparation classes on awareness and attitude of pregnant mothers toward

delivery type in Razi Hospital of Saravan, Revista Latinoamericana de Hipertensión. Vol. 13 - Nº 6, 2018,

http://saber.ucv.ve/ojs/index.php/rev_lh/article/view/15949.

[30] Seyed Basir Hashemi, Azita Amirfakhraei, Mina Mosallanezhad, Azadeh Amiri, The effect of education on

anxiety and self-efficacy in mothers of 1-3-year-old children under cochlear implant surgery, 2018: a

randomized controlled clinical trial, Revista Latinoamericana de Hipertensión. Vol. 14 - Nº1, 2019,

http://saber.ucv.ve/ojs/index.php/rev_lh/article/view/16170.

[31] Mahnaz Rakhshan, Khatereh Rostami, Elahe Setoodegan, Jamshid Eslami, The relationship between

leadership style and time management in senior and middle nursing managers, Revista Latinoamericana de

Hipertensión. Vol. 14 - Nº 1, 2019, http://saber.ucv.ve/ojs/index.php/rev_lh/article/view/16173.

[32] Khatereh Rostami, Farkhondeh Sharif, Ladan Zarshenas, Abbass Ebadi, Arash Farbood, Design and

Psychometrics of Measurement Tool of Health Needs in Patients with Chronic Back Ache, Revista

Latinoamericana de Hipertensión. Vol. 13 - Nº3, 2018, http://www.revhipertension.com/index_

sumario_3_2018.html.

[33] Rostami K, Zadeh SH, Rakhshan M. Chronic pain: a concept analysis. Electronic Journal of General

Medicine. 2019; 16(2).

[34] Rostami K, Ghodsbin F. Effect of Yoga on the Quality of Life of Nurses Working in Intensive Care Units.

Randomized Controlled Clinical Trial. Invest. Educ. Enferm. 2019; 37(3):e06.

[35] Leila Bazrafcan & Mitra Amini (2019): Using CRISIS model for designing master in medical education at

Shiraz University of Medical Sciences, Medical Teacher, DOI: 10.1080/0142159X.2018.1562540 To link

to this article: https://doi.org/10.1080/0142159X.2018.1562540.

[36] Laila Bazrafcan, Javad Kojuri & Mitra Amini (2019): Using SPICES educational strategy for

undergraduate curricular reform at Shiraz Medical School, Medical Teacher, DOI:

10.1080/0142159X.2019.1582759 To link to this article: https://doi.org/10.1080/0142159X.2019.1582759

[37] Eslami, J., Baghini, F.K., Moazamfard, M. The Effect of Music on the Stress Severity among the Staff of

Surgery Rooms. International Journal of Pharmaceutical Research, Volume 11, Issue 2, Apr - Jun, 2019,

PP. 838-843, http://ijpronline.com/ViewArticleDetail.aspx?ID=7339.

[38] Rafat Rezapour-Nasrabad, Application of Transitional Care Model in Patients with Chronic Heart Disease:

A Case-Controlled Intervention Study, Revista Latinoamericana de Hipertensión. Vol. 13 - Nº3, 2018,

http://www.revhipertension.com/index_sumario_3_2018.html

[39] Rafat Rezapour-Nasrabad, Transitional care model: managing the experience of hospital at home,

Electronic Journal of General Medicine, 2018; 15(5):em73, DOI: https://doi.org/10.29333/ejgm/93445,

http://www.ejgm.co.uk/Transitional-care-model-managing-the-experience-of-hospital-athome,93445,0,2.html.

[40] Abolfazl Gholamrezaei, Rafat Rezapour-Nasrabad, Mahdieh Ghalenoei, Malihe Nasiri, Correlation

between suicide literacy and stigmatizing attitude of nurses toward patients with suicide attempts, Revista

Latinoamericana de Hipertensión. Vol. 14 - Nº3, 2019, pp. 351-355.

[41] Batul Mozafari, Zahra Keshtkaran, Marzieh Momennasab, Narjes Nick, Saeedehpourahmad, Investigating

the Relationship between Health Literacy and Lifestyle in the Second-Grade High School Adolescents. The

Journal of Research on the Lepidoptera, September 2019, Volume 50 (3): 173-184,

[42] Fatemeh Vizeshfar, Marzieh Zare, Zahra Keshtkaran, Role-play versus lecture methods in community

health volunteers, Nurse Education Today, Volume 79, August 2019, Pages 175-179.

[43] Zahra Keshtkaran, Farkhondeh Sharif, Elham Navab & Sakineh Gholamzadeh, Lived Experiences of

Iranian Nurses Caring for Brain Death Organ Donor Patients: Caring as “Halo of Ambiguity and Doubt”,

Global Journal of Health Science; Vol. 8, No. 7; 2016.

[44] Keshtkaran, Z., et al., Students' readiness for and perception of inter-professional learning: A crosssectional study, Nurse Educ. Today (2014), http://dx.doi.org/10.1016/j.nedt.2013.12.008

[45] Zahra Keshtkaran*, Farkhondeh Sharif, Sakineh Gholamzadeh, Elham Navab, Compassionate Care Among

Iranian Nurses Caring for Candidate Brain Death Organ Donor Patients: A hermeneutic study, Revista

Latinoamericana de Hipertensión. Vol. 13 - Nº3, 2018, http://www.revhipertension.com/index_

sumario_3_2018.html

[46] Eghbal Sekhavati, Mojtaba Rahimian Boogar, Zahra Keshtkaran, Somayeh Kasharafifard, Jalal saem,

Identifying the stressors and usage of the coping strategies in clinical nurses. J Adv Pharm Edu Res 2018;

8(S2): 13-19.

[47] Somayeh Kasharafi Fard, Eghbal Sekhavati, Zahra Keshtkaran, Jalal saem, Impact of ten weeks interval

training on femoral strength and estrogen hormone. J Adv Pharm Edu Res 2018; 8(S2): 25-29.

[48] Eghbal Sekhavati, Zahra keshtkaran, Maryam Akbari, Somayeh kasharafifard, Jalal saem, Reza Tabrizi,

The study of epidemiological to attempted suicide in larestan city 2011-2014. J Adv Pharm Edu Res 2018;

8(S2): 20-24.

[49] Azita Amirfakhraei, Mehnoosh Hedayati, Mohammadreza Pirmoradi, Coping Styles with psychological

pressures in students of Iran University of medical sciences, International Journal of Pharmaceutical

Research, January- March 2019, Vol 11, Issue 1, pp. 534-537.

[50] Pirmoradi, M, Foroghinejad, N, Bedmeshki, FA. The relationship between job satisfaction and social

support for employees with chronic fatigue. Ann Trop Med Public Health 2017; 10:1681-5.

[51] Pirmoradi, M., Ghayoomi, R., Foroghinejad, N., Bedmeshki, F.A. The relationship between stressful life

events with chronic fatigue in employees of Ahvaz water and Sewage Company, Annals of Tropical

Medicine and Public Health-Special Issue Apr 2018 Vol. 13, pp. SX735-18.

[52] Mohammad Reza Pirmoradi, Fatemeh Sadeghi Poya, Mana Tabatabaee Rad, Fathemeh Veisy, Bahram

Gheitarani, Reza Davoodi and Shahrbanoo Ghahari, 2016. Comparison of Anxiety, Depression and Stress

and Emotional Self-Regulation in Normal and Divorced Women. International Journal of Tropical

Medicine, 11: 159-164.

[53] Bazrafkan L, Yousefy A, Amini M, Yamani N. The journey of thesis supervisors from novice to expert: a

grounded theory study. BMC medical education. 2019 Dec; 19(1):1-2.

[54] Bijani M, Ghodsbin F, Javanmardi Fard S, Shirazi F, Sharif F, Tehranineshat B, An evaluation of

adherence to ethical codes among nurses and nursing students, J Med Ethics Hist Med. 2017 Jul 5;10:6.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746660/

[55] Mostafa Bijani, Aboutaleb Haghshenas, Afsaneh Ghasemi, Evaluation of the Effect of Education Based on

Health Belief Model on Self-Therapy and Self-medication in Students at Fasa Medical Sciences

Dormitories, International Journal of Pharmaceutical Research, Jan-Mar 2019, Vol 11, Issue 3,

http://www.ijpronline.com/ViewArticleDetail.aspx?ID=7519

[56] Bijani Mostafa, Ghasemi Afsaneh, Karimi Shahnaz, Freidooni Zhila, Beygi Najimeh. The Role of

Educational Intervention Based on the Health Belief Model in Colorectal Cancer Screening of Teachers in

Fasa. Journal of Computational and Theoretical Nanoscience. Volume 16, Number 7, July 2019, pp. 2954-

2958(5).

[57] Mostafa Bijani, Khatereh Rostami, Afsaneh Ghasemi, Mahasti Emami, Zhila Fereidouni. Investigation of

diabetes prevention behaviors among teachers of different level of education based on Pender model in

selected educational centers in southwestern Iran, 2019. Revista Latinoamericana de Hipertensión. 2019.

Vol. 14 - Nº 4: 290-294

[58] Iwase A, Hirokawa W, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Manabe S, Kikkawa F. Serum

anti-Müllerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on

ovarian reserve. Fertil Steril. 2010; 94(7):2846-9.

[59] Kitajima M, Khan KN, Hiraki K, Inoue T, Fujishita A, Masuzaki H. Changes in serum anti-Müllerian

hormone levels may predict damage to residual normal ovarian tissue after laparoscopic surgery for women

with ovarian endometrioma. Fertil Steril. 2011; 95(8): 2589-91.

[60] Li CZ, Liu B, Wen ZQ, Sun Q. The impact of electrocoagulation on ovarian reserve after laparoscopic

excision of ovarian cysts: a prospective clinical study of 191 patients. Fertil Steril. 2009; 92(4):1428-35

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Published

31.10.2019

How to Cite

Modoodi, M., Zare, M., Nikbakht, R., Mirzaei, M., Bazrafkan, M., & Ataei, M. (2019). The Relationship between Functional Ovarian Cyst and Ovarian Reserve among Infertile Females. International Journal of Psychosocial Rehabilitation, 23(4), 1614-1622. https://doi.org/10.61841/edfrj962