STUDYING THE INFLUENCE OF FRACTIONAL COMPOSITION AND KINETICS OF MOISTURE SORPTION ON THE QUALITY OF CAPSULATED MASS AND CAPSULES“CELNINCIL”
DOI:
https://doi.org/10.61841/ee50rd88Keywords:
Capsules,, fractional composition, technology,, wet granulation,, moisture absorptionAbstract
This report presents experimental data on the influence of technological factors and humidity on the quality indicators of “Tselnincil” capsules of the selected composition, which was determined using mathematical planning of the experiment using the 3 × 4 Latin square method. The effect of fractional composition, relative humidity, and moisture absorption kinetics on the quality indicators of Tselnincil capsules was studied. The obtained results are used to test capsule technology in a production environment. The method and mode of granulation are selected.
Downloads
References
[1] Lopatin P.V. Methodological foundations of the creation and reproduction of drugs / P.V. Lopatin, L.E. Barabanov
// Priorities of pharmaceutical science and practice: Proc. Materials. Int. conf. (Moscow, October 31, 2005). M.: Publishing House of RUDN, 2006. - S.86-90.
[2] N.B.Shodieva, H.M. Yunusova. The study of the technological properties of the pressed mass of piracetam // Republican scientific journal "VESTNIK", Kazakhstan, 2014, Volume III-I, p. 102-104.
[3] Rebrova O. Yu. Statistical analysis of medical data. Application of the Statistica application package. M .: Media Sphere, 2002.312 s.
[4] Yezersky M.L. Methods for determining the technological characteristics of pharmaceutical powders. II. Bulk weight, bulk density, flowability, slope angle, adhesion, shear resistance. Chemical Pharmaceuticals Journal 1977; 11 (8): 97–114.
[5] ZelisonYu.I. New inventions of medicines in solid forms // Pharmacist. Moscow, 2006. No. 1.-C.3-4.
[6] State Pharmacopoeia XI, issue 2. Moscow “Medicine”, 1990.-S.154.
[7] Rubendra Kurmi, Dinesh Kumar Mishra, Dinesh Kumar Jain (2016) Solid Dispersion: A Novel Means Of Solubility Enhancement. Journal of Critical Reviews, 3 (1), 1-8.
[8] Dhanalakshmi,N.,Atchaya,S., &Veeramani,R. (2015). A Design of Multiband Antenna Using Main Radiator and Additional Sub-Patches for Different Wireless Communication Systems. International Journal of Communication and Computer Technologies, 3(1), 1-5.
[9] Pavithra,S.,Priyadharshini,A.,Praveena,V., & Monika,T. (2015). Paddy Leaf Disease Detection Using SVM Classifier. International Journal of Communication and Computer Technologies, 3(1), 16-20.
[10] Vautero, J. Sameness and continuity: The existence in a non-temporal space (2018) NeuroQuantology, 16 (8), pp. 39-47.
[11] Sonkaya, A.R. The use of functional near infrared spectroscopy technique in neurology (2018) NeuroQuantology, 16 (7), pp. 87-93.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
