What HR Managers need to know about Circadian Clocks?
DOI:
https://doi.org/10.61841/2d7e8c92Keywords:
Body clock, circadian clock, circadian cycle, , circadian rhyme, Circadian Rhyme DisruptionAbstract
The alteration of day and night, and changes in seasons has been instrumental in bringing out certain peculiar cyclic changes in the habits and behaviours of all living organisms. These cycles of the body known as “circadian cycles” help organisms to (re)act to varying stimuli in their internal and external environments, resulting in certain behavioural rhythms. Subsequent to the Industrial Revolution, humans started adapting the so called 24 x 7 type of life style. With competition raising its amorphous head due to liberalisation and globalisation, the lifestyles of humans have undergone a paradigm shift. This lifestyle often results in acting contrary to the circadian rhythms that have been set since generations, leading to various complications of astronomical proportions that have been unheard of in earlier generations. This work reviews the accumulated literature about circadian system and strives to find its applications in the present wellness programs. It also discusses the implications for HR Managers.
Key words-- , circadian clock, circadian cycle, circadian rhyme, Circadian Rhyme Disruption
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1. Abe, H., Honma, S., Namihira, M., et al. (1999). Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus. Brain Res Mol Brain Res., 66(1–2), 104–10.
2. Amaral, F. G., Castrucci, A. M., Cipolla-Neto, J., et al. (2014).Environmental control of biological rhythms: effects on development, fertility and metabolism. Journal of Neuroendocrinology,26(9), 603– 12.
3. Aschoff, J. and Honma, K. (1959). Z. Vergl. Physiology, 35, 481-600.
4. Bieber, R. M. (1990). Safety management is time management, Professional safety 35(1), 25-26.
5. Boivin, D. B. and Boudreau, P. (2014). Impacts of shift work on sleep and circadian rhythms. Pathol Biol (Paris), 62(5), 292–301.
6. Brower, K. K. J. (2001). Alcohol’s effects on sleep in alcoholics. Alcohol Research Health, 25, 110– 125.
7. Brown, J. R. and Antunano, M. J. (2009). Circadian Rhythm Disruption and Aviation, Publication No. AM-400-09/3, Federal Aviation Administration, Civil Aerospace Medical Institute. Available at www.faa.gov/pilots/safety/pilotsafetybrochures/
8. Chen, C. P., Kuhn, P., Advis, J. P. and Sarkar, D. K. (2004). Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Journal of Neurochemistry, 88, 1547–1554.
9. Cho, Y., Ryu, S. H, Lee, B. R., et al. (2015). Effects of artificial light at night on human health: A literature review of observational and experimental studies applied to exposure assessment. Chronobiol International,32(9), 1294–310.
10. Gillette, M. U. (1996). Prog. Brain Research, 111, 121-132.
11. Iijima, M., Nikaido, T., Akiyama, M., Moriya, T. and Shibata, S. (2002). Methamphetamine-induced, suprachiasmatic nucleus-independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse. European Journal of Neuroscience, 16, 921–929.
12. Kosobud, A. E. K., Gillman A. G., Leffel, J. K., Pecoraro, N. C., Rebec, G. V., Timberlake, W. (2007). Drugs of abuse can entrain circadian rhythms. Scientific World Journal, 7, 203–212.
13. Kuhlwein, E., Hauger, R. L. and Irwin, M. R. (2003). Abnormal nocturnal melatonin secretion and disordered sleep in abstinent alcoholics. Biological Psychiatry, 54, 1437–1443.
14. Landolt, H. P. and Gillin, J. C. (2001). Sleep abnormalities during abstinence in alcohol-dependent patients: Aetiology and management. CNS Drugs, 15, 413–425.
15. Madeira, M. D., Andrade, J. P., Lieberman, A. R., Sousa, N., Almeida, O. F., Paula-Barbosa, M. M. (1997). Chronic alcohol consumption and withdrawal do not induce cell death in the suprachiasmatic nucleus, but lead to irreversible depression of peptide immunoreactivity and mRNA levels. Journal of Neuroscience, 17, 1302–1319.
16. Martino, T. A., Tata, N., Belsham, D. D., et al. (2007). Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension,49(5), 1104– 1113.
17. Martino, T. A., Oudit, G. Y., Herzenberg, A. M., et al (2008).Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am Journal of PhysiolRegulIntegr Comp Physiol,294(5), 1675–1683.
18. Moore, R. Y. And Lenn, N. J. (1972). Journal of Comp. Neurology, 146, 1-14.
19. Gillette, M. U. and Tischkau, S. A. (1999). Suprachiasmatic Nucleus: The Brain’s Circadian Clock,
Recent Progress in Hormone Research, 54, 33-59.
20. Nic, P. (2012). Human body clock: what makes it tick? Occupational Health, 64, September, 9;
21. Ozburn, A. R. Falcon, E., Mukherjee, S., Gillman, A., Arey, R., Spencer, S. and McClung, C. A. (2013). The Role of Clock in Ethanol-Related Behaviors, Neuropsychopharmacology, 38, 2393–2400.
22. Rajakrishnan, V., Subramanian, P., Viswanathan, P., Menon, V. P. (1999). Effect of chronic ethanol ingestion on biochemical circadian rhythms in Wistar rats. Alcohol, 18, 147–152.
23. Reppert S. M. and Weaver, D. R. (2001). Molecular analysis of mammalian circadian rhythms. Annual Review of Physiology, 63, 647–676.
24. Reppert S, M., and Weaver, D. R. (2002). Coordination of circadian timing in mammals. Nature, 418, 935–941.
25. Rosenwasser, A. M., Fecteau, M. E., and Logan, R. W. (2005). Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats. Physiological Behavior, 84, 537–542.
26. Sano, H., Suzuki, Y., Yazaki, R., Tamefusa, K., Ohara, K., Yokoyama, T. et al. (1993). Circadian variation in plasma 5-hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects. Acta PsychiatrScand, 87, 291–296.
27. Sandhya, S. and Sulphey, M. M. (2019). An assessment of contribution of employee engagement, psychological contract and psychological empowerment towards turnover intentions of IT employees. International Journal of Environment, Workplace and Employment, 5 (1), 22-
31. http://doi:10.1504/IJEWE.2019.097186
28. Schwarts, W. J. (1993). Advances in Internal Medicine, 38, 81-106.
29. Seggio, J. A., Logan, R. W. and Rosenwasser, A. M. (2009). Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster. Pharmacology and Biochemistry of Behavior, 87, 297–305.
30. Sjoholm, L., Kovanen, L., Saarikoski, S., Schalling, M., Lavebratt, C. and Partonen, T. (2010). CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. Journal of Circadian Rhythms, 8: 1.
31. Spanagel, R., Rosenwasser, A. M., Schumann, G, and Sarkar, D. K., (2005). Alcohol consumption and the body’s biological clock. Alcohol Clinical Exp Research, 29, 1550–1557.
32. Stephan, F. K. (1984). Phase-shifts of circadian rhythms in activity entrained to food access. Physiology of Behavior, 32, 663–671.
33. Sulphey, M. M. &Alkahtani, N. S. (2017). Organizational ambidexterity as a prelude to corporate sustainability, Journal of Security and Sustainability Issues, 7 (2), 335-347. https://doi.org/10.9770/jssi.2017.7.2(13)
34. Sulphey, M. M. (2014). Construction & Validation of Employee Wellness Questionnaire, Indian Journal of Industrial Relations, 49 (4), 690-700.
35. Sulphey, M. M. (2019). Could adoption of Organizational Ambidexterity have changed the history of Nokia? South Asian Journal of Business and Management Cases, 8 (2), 167-
181. http://doi:10.1177/2277977919833752
36. Takahashi, J. S., Hong, H. K., Ko, C. H. and McDearmon, E. L. (2008). The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Review of Genetics, 9, 764– 775.
37. Verwey M, Dhir S and Amir S. (2016). Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease, F1000Research, 5, 2062 (doi: 10.12688/f1000research.9180.1)
38. Waterhouse, J., Reilly, T., Atkinson, G. and Edwards, B. (2007). Jet lag: trends and coping strategies,
The Lancet; 369, 1117-1129.
39. Woodfine, V. (2012). Watching the clock. The Safety & Health Practitioner, 30, 59-60.
40. Mikal Rekdal, Aravind Pai, Ravi Choudhari, MuddukrishnaBadamaneSathyanarayana. "Applications of Co-Crystals in Pharmaceutical Drugs." Systematic Reviews in Pharmacy 9.1 (2018), 55-57. Print. doi:10.5530/srp.2018.1.11
41. Bitbol, M. Consciousness, situations, and the measurement problem of quantum mechanics (2008) NeuroQuantology, 6 (3), pp. 203-213.
42. Wang, Q. Study of emotional changes based on neural management and electroencephalogram experiments on low-carbon consumption behavior (2018) NeuroQuantology, 16 (2), pp. 25-31.
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