The Role of Curcumin to PGF2a and the Primary Dysmenorrhea Pain Intensity
DOI:
https://doi.org/10.61841/grzrfd46Keywords:
Primary dysmenorrhea, Curcumin, Prostaglandin F2α (PGF2α)Abstract
The aim of the research is to rate the effectiveness of giving curcumin 7 days before menstruation in order to decrease the pain intensity of women with primary dysmenorrhea. The research is using randomized controlled trial method analysis with block permutation on women with primary dysmenorrhea. The statistical data was then processed using SPSS 21. The level of PGF2a in women that consume curcumin decreased significantly from 677.31 ± 387.27 to 419 ± 234.58 with the ratio P 0.001 compared to the control group. The average scale of the visual analog scale (VAS) also decreased significantly for women that were given curcumin supplementation, which was from 5.33 ± 1.56 to 2.67 ± 1.15 with the ratio P 0.000. The research has shown that supplementation of curcumin has certain role in decreasing the pain intensity and the prostaglandin F2A content in women with primary dysmenorrhea.
Downloads
References
1. Speroff L. Fritzz M. Clinical Gynecologic Endocrinology and Infertility, 7 ed. Philadelphia: Lippincot
William and Wilkins, 2011.
2. Gebeheyu MB., et al. Prevalence, Impact and Management Practice of Dysmenorrhea among University
of Gondar Students, Nothwestern Etiopia: A Cross Sectional Study. In Hindawi International Journal of
Reproduction Medicine; 2017.
3. Narsih et al. Efektivitas Penanganan Dismenore dengan Kompres Hangat dan Obat Anti Nyeri pada
Remaja Putri. Sains Med Jurnal Kesehatan. Surabaya. 2017; 9(1): 45-51.
4. Fortier MA., Krishnaswamy K., Danyod G. A Postgenomic integrated view of prostaglandin: Implication
for other body systems. Journal of Physiology and Pharmacology. 2008; 59: 65-89.
5. Clutterbuck AL., Allaway D., Harris P., Mobasheri A. Kurkumin reduces prostaglandin E2, matrix
metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage
[version 1; referees: 2approved] F1000Research. 2013; 2:147.
6. Ravindran RN., et al. Turmeric, the Genus Curcuma. CRC Press. New York; 2007.
7. Habibi et al. Prevalence of Primary Dysmenorrhea and Factors Associated with Its Intensity Among
Undergraduate Students: A Cross-Sectional Study. In : American Society for Pain Management Nursing;
2015. [Online]. Available: http://dx.doi.org/10.1016/j.pmn.2015.07.001[Accessed]
8. Burnet M, Lemyre M. Prmary Dysmenorrhea Concensus Guideline in SOGC Clinical Practice Guideline.
J Obstetry Gynecology. 2017; 39(7): 585-95.
9. Akbarzadeh M., Tayebi N., and Abootalebi M. The Relationship between Age at Menarche and Primary Dysmenorrhea in Female Students of Shiraz Schools. Shiraz E-Med J. 2017; 18(9): e14520.
10. Rafique N., Al-Sheikh MH. Prevalence of Primary Dysmenorrhea and Its Relationship with Body Mass
Index. J Obstet Gynecol R. 2018; 44(9): 1773-1778.
11. Chauhan M., Kala J. Relation between Dysmenorreha and Body Mass Index in Adolescents with Rural
versus urban variation. J Obstet Gynecol. 2012; 62(4): 442-445.
12. Lim R., Barker G., Wall CA., Lappas M. Dietary phytophenols curcumin, naringenin and apigenin reduce
infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and
myometrium. Molecular Human Reproduction. 2013; 19(7):451-62. doi: 10.1093/molehr/gat015.
13. Khayat S., Fanaei H., Kheirkhah M., Moghadam BZ., Kasaeian A., Javadimehr M. Curcumin attenuates
severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial.
Complementary Therapies in Medicine. 2015; 23(3): 318-324.
14. Marjoribanks J., Ayeleke RO., Farquhar C., Proctor M. Nonsteroidal anti-inflammatory drugs for
dysmenorrhoea. Cochrane Systematic Review, 2015. Available:
https://doi.org/10.1002/14651858.CD001751.pub3.
15. Kuptniratsaikul V., Dajpratham P., Taechharpornkul W., Buntragulpoontawee M., Lukkanapichonchut P.,
Chootip C., Saengsuwan J., Tantayakom K., Laongpech S. Efficacy and Safety of Curcuma Domestica
Extracts Compared With Ibuprofen in Patients With Knee Osteoarthritis: A Multicenter Study. Clin Interv
Aging. 2014; 9: 451-8. doi: 10.2147/CIA.S58535.
16. Smith RP. Dysmenorrhea and Menorrhagia A Clinician’s Guide. Switzerland: Springer; 2018.
17. Nulanda M., Rambulangi J., Lukas E. Efek pemberian α-tokoferol terhadap kadar prostaglandin plasma sebagai terapi dismenore primer. UMI Medical Journal. 2019; 4(1): 76-91.
18. Dawood M. Primary Dysmenorrhea Advances in Pathogenesis and Management Journal Obstetric and Gynecology. 2006; 108.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
