Oxidative Stress and Insulin Resistance Among Polycystic Ovary Syndrome Patients. A Cross-Sectional Study In Makassar, Indonesia
DOI:
https://doi.org/10.61841/8p79rz56Keywords:
polycystic ovary syndrome, oxidative stress, insulin resistanceAbstract
This study aims to know the relationship between levels of oxidative stress and the incidence of insulin resistance in patients with Polycystic Ovary Syndrome (PCOS). This is an observational study with a cross-sectional approach. Samples of 27 patients with insulin resistance confirmed by IR HOMA > 2 and 27 patients without insulin resistance confirmed by HOMA IR < 2, then all subjects were tested for reactive oxygen species (ROS) levels using the enzyme-linked immunosorbent assay (ELISA) method from January to December 2019. The average level of reactive oxygen species (ROS) was 1.58, and the average value of HOMA-IR was 2.91. There was a significant relationship between the ROS levels and the value of HOMA IR in patients with Polycystic Ovary Syndrome (PCOS) (p = 0.001; p <0.05). This study concludes that a significant relationship between ROS and insulin resistance (HOMA-IR) is based on the mechanism of hyperglycemia due to insulin resistance resulting in an increase in reactive oxygen species (ROS), which results in hyperandrogenic conditions in patients with Polycystic Ovary Syndrome (PCOS).
Downloads
References
1. Agarwal, A., Virk, G., Ong, C., et. al. 2014. Effect of Oxidative Stress on Male Reproduction. World J Mens Health, 32, 1-17.
2. Brodell, L. A. & Mercurio, M. G. (2010). Hirsutism: Diagnosis and management. Gender Medicine, 7(2), 79-87. DOI:10.1016/j.genm.2010.04.002
3. Carmina, E. 2012. SOPK: metabolic impact and long-term management. Minerva Ginecol, 64, 501-506.
4. Desai, VaralaKshmi, Namburi RajeNDra PrasaD, and Suchitra musturu maNohar. Oxidative Stress in Non-Obese Women with Polycystic Ovarian Syndrome. Journal of Clinical and Diagnostic Research. 2014;
8(7): CC01-CC03. DOI: 10.7860/JCDR/2014/8125.4530.
5. Fritz, M. A. & Speroff, L. 2011. Chronic anovulation and polycystic ovary syndrome. In: Seigafuse, S.
(ed.) Clinical gynecologic endocrinology and infertility. USA: Wolters Kluwer Health/Lippincott
Williams and Wilkins.
6. Kabel, A. M. 2016. Polycystic Ovarian Syndrome: Insights into Pathogenesis, Diagnosis, Prognosis,
Pharmacological and non-pharmacological treatment. Journal of Pharmacological Reports, 1, 1-5.
7. Karima, P., and Hestiantoro A. The Cutoff of Ferriman Gallwey Score for PCOS in Asia and the Degree
of Hyperandrogenism Indicator, ASPIRE Conference Proceedings, The 6th Congress of the Asia Pacific
Initiative on Reproduction, KnE Medicine. 2016: Pp. 186-192. DOI: 10.18502/kme.v1i1.640.
8. Liguori, Ilaria, Gennaro Russo, Francesco Curcio, et al., Oxidative stress, aging, and diseases. Clinical
Interventions in Aging. 2018;13: pp. 757-772.
9. Lu, J. Y., Wang, Z. X., Cao, J., et. al. 2018. A Novel and Compact Review on The Role of Oxidative Stress
in Female Reproduction. Reproductive Biology and Endocrinology, 16, 1-18.
10. Lucidi, R. S. 2018. Polycystic Ovarian Syndrome [online]. Virginia: Medscape. Available:
https://emedicine.medscape.com/article/256806-overview#showall [Accessed 20 April 2018].
11. McCartney, C. R. & Marshall, J. C. 2016. Polycystic Ovary Syndrome. N Engl J Med, 375, 54-64.
12. Moti M, Amini L, Mirhoseini Ardakani SS, Kamalzadeh S, Masoomikarimi M, Jafarisani M. Oxidative
stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome. Iran J Reprod
Med. 2015;13(6):373-378.
13. Nidhi. R, Padmalatha V, Nagarathna R, and Amritanshu R. Prevalence of polycystic ovarian syndrome in
Indian adolescents. J Pediatr Adolesc Gynecol. 2011; 24(4):223-7. DOI:10.1016/j.jpag.2011.03.002
14. O'Reilly, M. W., Taylor, A. E., Crabtree, N. J., et. al. 2014. Hyperandrogenemia Predicts Metabolic
Phenotype in Polycystic Ovary Syndrome: The Utility of Serum Androstenedione. J Clin Endocrinol
Metab, 99, 1027-1036.
15. Pizzino, G, Irrera, N, Cucinotta, M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid
Med Cell Longev. 2017: 8416763. DOI:10.1155/2017/8416763.
16. Schattman, G. L., Esteves, S. C., & Agarwal, A. 2015. Unexplained Infertility: Pathophysiology, Evaluation
and Treatment, New York, Springer.
17. Setiawan, B. & dkk 2005. Stres oksidatif dan peran antioksidan pada diabetes melitus. Majalah Kedokteran
Indonesia, 55.
18. Sulaiman, MA, Al-Farsi YM, Al-Khaduri MM, Saleh J, and Waly MI. Polycystic ovarian syndrome is
linked to increased oxidative stress in Omani women. Int J Womens Health. 2018; 10: 763-771.
DOI:10.2147/IJWH.S166461.
19. Turan, V., Mizrak, S., Yurekli, B., et. al. 2013. The effect of long-term nicotine exposure on bone mineral density and oxidative stress in female Swiss Albino rats. Arch Gynecol Obstet, 287, 281-287.
20. Victor, Victor M., Susana Rovira-Llopis, Celia Bañuls, et al., Insulin Resistance in PCOS Patients Enhances Oxidative Stress and Leukocyte Adhesion: Role of Myeloperoxidase. PLoS ONE. 2016; 11(3): e0151960. DOI:10.1371/journal.pone.0151960
21. Wahyuni, M. & dkk 2015. Hubungan Resistensi Insulin dengan Gambaran Klinis Sindrom Ovarium
Polikistik. Jurnal Fakultas Kedokteran Universitas Andalas Padang, 4.
22. Yidiz, B., Yarali, H., Oguz, H., et. al. 2003. Glucose intolerance, insulin resistance, and hyperandrogenemia
in first-degree relatives of women with polycystic ovarian syndrome. J Clinc Endocrinol Metab, 88, 2031.
23. Zhang, Jingshun, Yigang Bao, Xu Zhou, and Lianwen Zheng. Polycystic ovary syndrome and mitochondrial dysfunction. Reproductive Biology and Endocrinology. 2019; 17:67. DOI : https://doi.org/10.1186/s12958-019-0509-4.
24. Zuo, T, Zhu M, and Xu W. Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers. OxidMed Cell Longev. 2016; 8589318. DOI:10.1155/2016/8589318.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
