The Correlation between Anti-Mullerian Hormone Levels and The Number of Oocyte Retrieved and Pregnancy Rate in Infertile Women Who Underwent IVF in Makassar City
DOI:
https://doi.org/10.61841/ftcfkf46Keywords:
AMH, oocyte, pregnancy rate, IVFAbstract
Anti-Mullerian hormone (AMH) being a good marker for ovarian response. Decreased serum AMH levels may be indicative for poor response in vitro fertilization (IVF) in women with a diminished ovarian reserve This study aims to determine the serum level of AMH correlation with the number of oocyte retrieved and pregnancy rate in infertile women. This cross-sectional study was eligible for 254 infertile women who underwent in vitro fertilization in private IVF Clinic in Makassar. AMH serum levels were measured on cycle day 3. The number of oocytes were determined on the day of oocyte retrieval. Pregnancy was determined by the β- hCG test on day 16 of the cycle. Serum AMH levels show a significant negative correlation with women <35 years (r = -0.178; p = 0.029) and a negative correlation but not significant with women age ≥35 years (r = -0.144; p = 0.144). Conversely, AMH levels and the number of oocyte retrieved show a significant positive correlation (r = 0.507, = 0.000). Chemical pregnancy does not correlate with AMH levels (p >.05). The AMH levels and the number of oocytes retrieved might predict the ovarian function. AMH levels could not predict the pregnancy rates.
Downloads
References
1. Anderson RA. What does anti-Müllerian hormone tell you about ovarian function? Clin Endocrinol.
2012;77(5):652-55.
2. Durlinger AL, Gruijters MJ, Kramer P, et al. Anti-Müllerian hormone attenuates the effects of FSH on
follicle development in the mouse ovary. Endocrinology. 2001;142:4891-9.
3. Durlinger AL, Gruijters MJ, Kramer P, et al. Anti-Müllerian hormone attenuates the effects of FSH on
follicle development in the mouse ovary. Endocrinology. 2001;142:4891-9.
4. Fanchin R, Schonauer LM, Righini C, et al. Serum anti-Mullerian hormone dynamics during controlled
ovarian hyperstimulation. Hum Reprod 2003;18:328-332.
5. Fong SL, Baart EB, Martini E, et al. Anti-Müllerian hormone: a marker for oocyte quantity, oocyte quality, and embryo quality? Reprod Biomed Online. 2008;16:664-70.
6. Gupta S, Karuputhula N, Kumar N, et al. Correlation of basal serum anti-Mullerian hormone level with oocyte quality and embryo development potential in women undergoing IVF-ICSI. Fertil Sci Res 2017;4:112-6.
7. Irez T, Ocal P, Guralp O, et al. Different serum anti-Mullerian hormone concentration are associated
with oocyte quality, embryo development parameters, and IVF-ICSI outcomes. Arch Gynecol Obset
2011;284:1295-301.
8. Ishii R, Tachibana N, Okawa R, et al. Different anti-Műllerian hormone (AMH) levels respond to
distinct ovarian stimulation methods in assisted reproductive technology (ART): challenges to better ART
outcomes. Reprod Med Biol. 2019;18(3):263–272.
9. Ishii R, Tachibana N, Okawa R, et al. Different anti‐Műllerian hormone (AMH) levels respond to
distinct ovarian stimulation methods in assisted reproductive technology (ART): challenges to better ART
outcomes. Reprod Med Biol. 2019;18:263–272.
10. Kevenaar ME, Themmen AP, Laven JS, et al. Anti-Müllerian hormone and anti-Müllerian hormone type
II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory
women. Hum Reprod. 2007;22:1547-54.
11. Kevenaar ME, Themmen AP, Laven JS, et al. Anti-Müllerian hormone and anti-Müllerian hormone type
II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory
women. Hum Reprod. 2007;22:1547-54.
12. La Marca A, Malmusi S, Giulini S, et al. Anti-Mullerian hormone plasma levels in spontaneous
menstrual cycle and during treatment with FSH to induce ovulation. Hum Reprod 2004;19:2738–2741.
13. Laven JS, Mulders AG, Visser JA, et al. Anti-Mullerian hormone serum concentrations in
normoovulatory and anovulatory women of reproductive age. J Clin Endocrinol Metab 2004;89:318-23.
14. Lee JR, Kim SH, Kim SM, et al. Anti-Mullerian hormone dynamics during controlled ovarian
hyperstimulation and optimal timing of measurement for outcome prediction. Hum Reprod.
2010;25(10):2597-604.
15. Lie SL, Lugtenburg PJ, Schipper I, et al. Anti-mullerian hormone as a marker of ovarian function in
woman after chemotherapy and radiotherapy for hematological malignancy. Hum Reprod.
2008;23(3):674-8.
16. Massague´ J. The transforming growth factor-b family. Annual Review of Cell Biology. 1990;6:597–
641.
17. Peigne M, Decanter C. Serum AMH level as a marker of acute and long-term effect of chemotherapy on
ovarian follicular content. Reprod Biol Endocrinol. 2014;12:26.
18. Re-Enner T, Sommergruber M, Moser M, et al. Bsal level of anti-Muellerian hormone is associated with
oocyte quality in stimulated cycles. Hum Reprod 2006;21:2022-6.
19. van Rooij IA, Broekmans FJ, Scheffer GJ, et al. Serum antiMullerian hormone levels best reflect the
reproductive decline with age in normal women with proven fertility: A longitudinal study. Fertil Steril
2005;83:979-87.
20. Zargar M, Najafian M, Z. Zamanpour Z. Relationship between follicular fluid and serum anti-Mullerian
hormone levels and pregnancy rate in ART cycles. Perinatol Reprod Hum 2018;32(1):3-8.
21. Zhang B, Meng Y, Jiang X, et al. IVF outcomes of women with discrepancies between age and serum anti-Müllerian hormone levels. Reproductive Biology and Endocrinology 2019;17:58.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
