Study of Biochemical Changes during Treatment of Kidney Stone and Urinary Tract Infection with Herbal Drug

Authors

  • Nandu Baby P. Ph.d Student, Department of Biochemistry, Bharath Institute of Higher Education & Research, Chennai Author
  • Dr.V. Ramesh Supervisor & Associate Professor, Department of Biochemistry, Bharath Institute of Higher Education & Research, Chennai. Author

DOI:

https://doi.org/10.61841/45q8mq26

Keywords:

Urinary Tract Infection, Kidney Stone, Herbal Drugs

Abstract

A fewer communal category of pebble is produced by the contamination in the urinary area. This pebble is termed a contamination pebble. The herbal drug has remained well-known for eras and is vastly valued everywhere in the ecosphere as an abundant basis of healing representatives for the anticipation of several illnesses. The current investigation was to test the biochemical test finding before and after therapy with herbal drugs in patients with kidney stones and UTIs.  The investigation was based on 210 cases of kidney disorders in the medical lab center, from which 105 were suffering from kidney stones, and 105 were with urinary tract infections. Urine and blood samples were collected from them for conducting blood biochemical parameters and serological tests for UTI. The patients took an average of 6 tablets a day, corresponding to standard dosage procedures. Before treatment, the kidney stone groups were compared concerning the severity of stone disease with the control group. The group stone formation rates were found to have an insignificant difference with that of the control group. In the case of the ‘Serum Glucose' level, it was found to have a significant difference between the before and control groups (89.742±1.074 and 85.81±5.63). In the current study, the positive connection between biochemical parameters and herbal drugs and allopathic drug therapy stretches maintenance to the rate of recovery in both kidney stones and UTIs. The upcoming natural herbal yields will be challenging new drugs through additional benefits of added protection as well as lesser prices.

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References

[1] O.W. Moe. Kidney stones: pathophysiology and medical management. The lancet, 367(9507), 2006, 333-

344.

[2] G.C. Curhan, W.C. Willett, E.L. Knight, M.J. Stampfer. Dietary factors and the risk of incident kidney

stones in younger women: Nurses' Health Study II. Archives of Internal Medicine, 164(8), 2004, 885-891.

[3] D.W. Killilea, J.L. Westropp, R. Shiraki, M. Mellema, J. Larsen, A.J. Kahn, M.L. Stoller. Elemental

content of calcium oxalate stones from a canine model of urinary stone disease. PloS one, 10(6), 2015,

e0128374.

[4] O. Devuyst, Y. Pirson. Genetics of hypercalciuric stone-forming diseases. Kidney international, 72(9),

2007, 1065-1072.

[5] D.S. Goldfarb. Nephrolithiasis. Annals of internal medicine, 151(3), 2009, ITC2-1.

[6] J.H. Parks, M. Coward, F.L. Coe. Correspondence between stone composition and urine super saturation in

nephrolithiasis. Kidney International, 51(3), 1997, 894-900.

[7] J.H. Parks, M. Coward, F.L. Coe. Correspondence between stone composition and urine super saturation in

nephrolithiasis. Kidney international, 51(3), 1997, 894-900.

[8] S.R. Khan, M.S. Pearle, W.G. Robertson, G. Gambaro, B.K. Canales, S. Doizi, H.G. Tiselius. Kidney

stones. Nature Reviews Disease Primers, 2, 2016, 16008.

[9] V.K. Sigurjonsdottir, H.L. Runolfsdottir, O.S. Indridason, R. Palsson, V.O. Edvardsson. Impact of

nephrolithiasis on kidney function. BMC nephrology, 16(1), 2015, 149.

[10] Z.M. El-Zoghby, J.C. Lieske, R.N. Foley, E.J. Bergstralh, , X. Li, , L.J. Melton, A.D. Rule. Urolithiasis and

the risk of ESRD. Clinical Journal of the American Society of Nephrology, 2012, CJN-03210312.

[11] B.R. Waterman, B.D. Owens, S. Davey, M.A. Zacchilli, P.J. BelmontJr. The epidemiology of ankle sprains

in the United States. JBJS, 92(13), 2010, 2279-2284.

[12] T.M. Hooton. Uncomplicated urinary tract infection. New England Journal of Medicine, 366(11), 2012,

1028-1037.

[13] G.R. Nielubowicz, H.L. Mobley. Host–pathogen interactions in urinary tract infection. Nature Reviews

Urology, 7(8), 2010, 430.

[14] B. Foxman. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and

disease burden. Infectious disease clinics of North America, 28(1), 2014, 1-13.

[15] T.J. Hannan, M. Totsika, K.J. Mansfield, K.H. Moore, M.A. Schembri, S.J. Hultgren. Host–pathogen

checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli

bladder infection. FEMS microbiology reviews, 36(3), 2012, 616-648.

[16] Kostakioti, M., Hultgren, S.J., & Hadjifrangiskou, M. (2012). Molecular blueprint of uropathogenic

Escherichia coli virulence provides clues toward the development of anti-virulence

therapeutics. Virulence, 3(7), 592-593.

[17] S. Subashchandrabose, T.H. Hazen, A.R. Brumbaugh, S.D. Himpsl, S.N. Smith, R.D. Ernst, H.L. Mobley.

Host-specific induction of Escherichia coli fitness genes during human urinary tract infection. Proceedings

of the National Academy of Sciences, 111(51), 2014, 18327-18332.

[18] R. Rajavel, P. Mallika, V. Rajesh, K. Pavan Kumar, S. Krishna Moorthy, T. Sivakumar. Antinociceptive

and Antiinflammatory Effects of the Methanolic extract of Oscillatoria annae. Res J Chem Sci, 2(7), 2012,

53-61.

[19] M. Ahmed, B.K. Datta, & A.S.S. Rouf. Rotenoids from Boerhaavia repens. Phytochemistry, 29(5), 1900,

1709-1710.

[20] N. Lami, S. Kadota, Y. Tezuka, & T. Kikuchi. Constituents of the Roots of Boerhaavia diffusa L. II.:

Structure and Stereochemistry of a New Rotenoid, Boeravinone C. Chemical and Pharmaceutical

Bulletin, 38(6), 1900, 1558-1562.

[21] S. Kadota, N. Lami,Y. Tezuka, & T. Kikuchi. Constituents of the Roots of Boerhaavia diffusa LI:

Examination of Sterols and Structures of New Rotenoids, Boeravinones A and B. Chemical and

Pharmaceutical Bulletin, 37(12), 1989, 3214-3220.

[22] N. Lami, S. Kadota, T. Kikuchi. Constituents of the roots of Boerhaavia diffusa L. IV. Isolation and

structure determination of boeravinones D, E, and F. Chemical and Pharmaceutical Bulletin, 39(7), 1991,

1863-1865.

[23] R.K. Seth, M. Khanna, M. Chaudhary, S. Singh, J.P.S. Sarin. Estimation of punarnavosides, a new

antifibrinolytic compound from Boerhaavia diffusa. Indian Drugs, 23(10), 1986, 583-4.

[24] N.L. Oburai, V.V. Rao, R.B.N. Bonath. Comparative clinical evaluation of Boerhavia diffusa root extract

with standard Enalapril treatment in Canine chronic renal failure. Journal of Ayurveda and integrative

medicine, 6(3), 2015, 150.

[25] S.K. Pareta, K.C. Patra, P.M. Mazumder, D. Sasmal. Aqueous extract of Boerhaavia diffusa root

ameliorates ethylene glycol-induced hyperoxaluric oxidative stress and renal injury in rat

kidney. Pharmaceutical biology, 49(12), 2009, 1224-1233.

[26] J.P. Mishra. Studies on the effect of indigenous drug Boerhaavia diffusa Rom. on kidney

regeneration. Indian Journal of Pharmacy, 12(59), 1980, 1487-98.

[27] T. Alelign, B. Petros. Kidney Stone Disease: An Update on Current Concepts. Advances in urology, 2018.

[28] A.L. Flores-Mireles, J.N. Walker, M. Caparon, S.J. Hultgren. Urinary tract infections: epidemiology,

mechanisms of infection and treatment options. Nature reviews microbiology, 13(5), 2015, 269.

[29] A.R. Mahesh, H. Kumar, M.K. Ranganath, R.A. Devkar. Detail study on Boerhaavia diffusa plant for its

medicinal importance-A Review. Research Journal of Pharmaceutical Sciences, 1(1), 2012, 28-36.

[30] M.L. Wilson, L. Gaido. Laboratory diagnosis of urinary tract infections in adult patients. Clinical infectious

diseases, 38(8), 2004, 1150-1158.

[31] V. Gohil Unnati, M. Vipul, M.V. Patel, S.N. Gupta, K.B. Patel. Polyherabal Treatment for Chronic Kidney

Disease – A Case Study. Universal Journal of Pharmacy. 02 (04), 2013, 44-47.

[32] D.Barham, P. Trinder. An improved colour reagent for the determination of blood glucose by the oxidase

system. Analyst, 97(1151), 1972, 142-145.

[33] NW Tietz. Clinical guide to laboratory test. 2006. 4th ed. p. 1096- 1099.

[34] D. Labbe, A. Vassault, B. Cherruau, P. Baltassat, R. Bonete, G. Carroger, A. Nicolas. Method selected for

the determination of creatinine in plasma or serum. Choice of optimal conditions of measurement. In

Annales de biologie Clinique, 54(8), 1996, pp. 285-298).

[35] R.J. Henry, D.C. Cannon, J.W. Winkelman. Principles and techniques. Clinical Chemistry, 2nd Ed. Harper

and Row, 1974, 525.

[36] N.W. Tietz. Fundamentals of Clinical Chemistry, Saunders, Philadelphia, 2006, 4th Edit., 984.

[37] J. Stern, W.H.P. Lewis. The colorimetric estimation of calcium in serum with O-cresolphthalein

complexone. Clinica Chimica Acta, 2(6), 1957, 576-580.

[38] E.S. Baginski, P.P. Foa, B. Zak. Determination of phosphate: study of labile organic phosphate

interference. Clinica Chimica Acta, 15(1), 1967, 155-158.

[39] P. Trinder. Determination of glucose in blood using glucose oxidase with an alternative oxygen

acceptor. Annals of clinical Biochemistry, 6(1), 1969, 24-27.

[40] C.C. Allain, L.S. Poon, C.S. Chan, W.F.P.C. Richmond, P.C. Fu. Enzymatic determination of total serum

cholesterol. Clinical chemistry, 20(4), 1974, 470-475.

[41] P. Fossati. Prencipe. L. Serum TG determination colorimeterically with on enzyme that produces

inflammatory reaction. Am. j. pathol, 1982, 107-397.

[42] M.T. Yakubu, L.S. Bilbis, M. Lawal, M.A. Akanji. Evaluation of selected parameters of rat liver and

kidney function following repeated administration of yohimbine. Biokemistri, 15(2), 2003, 50-56.

[43] B.L. Craven, C. Passman,D. G. Assimos. Hypercalcemic states associated with nephrolithiasis. Reviews in

urology, 10(3), 2008, 218.

[44] M. Daudon, O. Traxer, P. Conort, B. Lacour, P. Jungers. Type 2 diabetes increases the risk for uric acid

stones. Journal of the American Society of Nephrology, 17(7), 2006, 2026-2033.

[45] H.S. Chen, L.T. Su, S. Z. Lin, F.C. Sung, M.C. Ko, C.Y. Li. Increased risk of urinary tract calculi among

patients with diabetes mellitus—a population-based cohort study. Urology, 79(1), 2012, 86-92.

[46] B.J. Ansell, K.E. Watson, A.M. Fogelman, M. Navab, G.C. Fonarow. High-density lipoprotein function:

recent advances. Journal of the American College of Cardiology, 46(10), 2005, 1792-1798.

[47] N. Johnkennedy, O. Chinedu, N. Richard, I. Chinedu, O. Chinyere, E. Ukamaka. Investigations on serum

lipid profile in patients with urinary tract infections. Global Journal of Scientific Researches, 1(3), 2013,

68-70.

[48] C. Alvarez, A. Ramos. Lipids, lipoproteins, and apoproteins in serum during infection. Clinical

chemistry, 32(1), 1986, 142-145.

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Published

31.05.2020

How to Cite

P. , N. B., & V. , R. (2020). Study of Biochemical Changes during Treatment of Kidney Stone and Urinary Tract Infection with Herbal Drug. International Journal of Psychosocial Rehabilitation, 24(3), 1026-1032. https://doi.org/10.61841/45q8mq26