Activity of Monooxygenase and Nitrogenous Systems in Liver Microsomes Under the Influence of Inducers and Inhibitors of Medicinal Metabolism on the Organism in Conditions of Liver Pathology
DOI:
https://doi.org/10.61841/y5bgjq79Keywords:
monooxygenase, NO-system, benzonal, cimethedrine, hepatitis, nitrogen oxide, endothelial nitric oxide synthase, inducible nitrogen oxide synthase, peroxynitrite, cytochrome P450Abstract
In experiments on 48 white-breed rats of males with a mass of 180-250 g. it was found that benzenol in an effective dose of 75 mg/kg had a favorable effect on the monooxygenase and nitration system of hepatocyte microcircuits of rats with acute liver damage, while cimetidine in a dose of 10 mg/kg further suppressed the activity of MCO, increased the formation of toxic radicals NO, leading to an even greater aggravation of the severity of the animals.
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