Antibacterial Activity of Zingiber officinale Rhizome

Authors

  • Maulana Yusuf Alkandahri M.Pharm., Apt. Faculty of Pharmacy, Buana Perjuangan University, Karawang, West Java, Indonesia. Author
  • Anggun Hari Kusumati Faculty of Pharmacy, Buana Perjuangan University, Karawang, West Java, Indonesia Author
  • Lia Fikayuniar Faculty of Pharmacy, Buana Perjuangan University, Karawang, West Java, Indonesia Author

DOI:

https://doi.org/10.61841/568sve73

Keywords:

Antibacterial Activity, Manoko Plantation, Bandung, West Java

Abstract

Background: The aim of this study was to determine the antibacterial activity and phyto-chemical screening of the Zingiber officinale ethanol extract. Fresh rhizomes of Z. officinale (Ginger) are collected from Manoko Plantation in Bandung, West Java, Indonesia. Methods: Antibacterial activity was determined using the well diffusion method while phytochemical screening was performed to determine the phytochemical composition of the ginger rhizome. Results: Results of phytochemical screening revealed phenolic compounds, alkaloids, flavonoids, tannins, and terpenoids. Results for bioassay presented variations in the biological activity of the extract. The extract showed antibacterial activity against all bacteria tested with inhibition diameter zones ranging from 2.67 to 12.47 mm mm. The highest zone was observed in Staphylococcus aureus at 400 mg/ml while the smallest inhibition zone was observed in Pseudomonas aeruginosa at 100 mg/ml. Conclusion: Our research proves that Z. officinale rhizome extract has the ability to inhibit bacterial growth. This shows that Z. officinale can potentially be used to develop new agents for combat bacteria. However, further studies are needed to explain the mechanism behind these effects. 

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References

[1] Triana, D. Frekuensi β-Lactamase hasil Staphylococcus aureus secara iodometri di laboratorium mikrobiologi fakultas kedokteran universitas andalas. Jurnal Gradien . 2014. 10(2).

[2] Kemenkes RI. Riset kesehatan dasar. Badan Penelitian dan Pengembangan Kesehatan. Jakarta. 2008.

[3] Nursal W, Sri, Wilda S. Bioaktifitas ekstrak jahe (Zingiber officinale Roxb.) dalam menghambat pertumbuhan koloni bakteri Escherichia coli dan Bacillus subtilis. Jurnal Biogenesis. 2006;2(2):64-66.

[4] Harbone JB. Phytochemical methods: A guide to modern techniques of plant analysis. Chapman and Hall, New York, USA. 1973;3:100-117.

[5] Kirby-Bauer A. Antimicrobial sensitivity testing by agar diffusion method. J Clin Pathol. 1996;44:493.

[6] Zgoda JR, Porter JR. A convenient microdilution method of screening natural products against bacteria and fungi. Pharm Book. 2001;39:221-225.

[7] National Committee for Clinical Laboratory Standard (NCCLS). Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals. Approved Standard. 2002;p: 28.

[8] Xie Y, Yang W, Tang F, Chen X, Ren L. Antibacterial activities of flavonoids: structure-activity relationship and mechanism. Curr Med Chem. 2015;22(1):132-49.

[9] Mabhiza, D, Chitemerere, T, Mukanganyama, S. Antibacterial properties of alkaloid extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa. International Journal of Medicinal Chemistry. 2016;1-8.

[10] Lucchini JJ, Corre J, Cremieux A. Antibacterial activity of phenolic compounds and aromatic alcohols. Res Microbiol. 1990;141(4):499-510.

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Published

29.02.2020

Issue

Vol. 24 No. 1 (2020): 24 (1) 2020

Section

Articles

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How to Cite

Yusuf Alkandahri, M., Hari Kusumati, A., & Fikayuniar, L. (2020). Antibacterial Activity of Zingiber officinale Rhizome. International Journal of Psychosocial Rehabilitation, 24(1), 8604-8608. https://doi.org/10.61841/568sve73