Anti inflammatory Activity of MangiferaIndica Peel
DOI:
https://doi.org/10.61841/e7ww6m82Keywords:
mangiferaindica, antiinflamatory, peel, antioxidant, mangoAbstract
Mangifera indica (commonly known as mango) is a widely used herb in Ayurvedic medicine. Although numerous review articles on this plant are already published, this review article aims to compile all updated information on its phytochemical and pharmacological activities, assessed through various methods. Studies indicate that mango possesses antidiabetic, antioxidant, antiviral, cardiotonic, hypotensive, and anti-inflammatory properties.
Aim: The aim of the study is to investigate the in vitro anti-inflammatory activity of *Mangifera indica* peels.
Method: The reaction mixture consisted of the test extract at different concentrations and a 1% aqueous solution of bovine albumin fraction. The pH of the reaction mixture was adjusted using a small amount of 1N HCl. The samples were incubated at 37°C for 20 minutes, then heated at 57°C for an additional 20 minutes. After cooling, the samples' turbidity was measured spectrophotometrically at 660 nm.
The experiment was performed in triplicate.
Result: Protein denaturation is a well-documented cause of inflammation. In investigating the mechanism of the anti-inflammatory activity, the extract's ability to inhibit protein denaturation was studied.
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References
1. Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J
Ethnopharmacol. 2000;71:23–43. [PubMed]
2. Khan MN, Nizami SS, Khan MA, Ahmed Z. New saponins from MangiferaIndica. J Nat Prod.
1993;56:767–70.
3. Shankarnarayanan D, Gopalakrishman C, Kameswaran L, Arumugum S. The effect of mangostin,
mangostin-3, 6-di-O-glucoside and Mangiferin in carbon tetrachloride liver injury. Mediscope.
1979;22:65.
4. Khan MA, Khan MN. Alkyl gallates of flowers of MangiferaIndica. Fitoterapia. 1989;60:284.
5. Ross IA. Vol. 1. New Jersey Totowa: Human Press; 1999. Medicinal plants of the world; pp. 199–200.
6. Shibahara A, Yamamoto K, Shinkai K, Nakayama T, Kajimoto G. Cis-9, cis-15-octadecadienoic acid:a novel fatty acid found in higher plants. BiochimiBiophyActa. 1993;1170:245–52.
7. Nunez Selles AJ, Vélez Castro HT, Agüero-Agüero J, Gonzalez-Gonzalez J, Naddeo F, De Simone F, et al. Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from Mango (MangiferaIndica L.) stem bark aqueous decoction used in cuba as a nutritional supplement. J Agric Food Chem. 2002;50:762–6.
8. Andreas S, Wieland U, Reinhold C. Characterization of polyphenols in mango puree concentrate by
HPLC with diode array and mass spectrometric detection. Int J Food SciNutr. 2000;1:161–6.
9. Pott I, Marx M, Neidhart S, Mühlbauer W, Carle R. Quantitative determination of beta-carotene
stereoisomers in fresh, dried, and solar-dried mangoes (MangiferaIndica L.) J Agric Food Chem.
2003;51:4527–31.
10. Chen JP, Tai CY, Chen BH. Improved liquid chromatographic method for determination of carotenoids
in Taiwanese mango (MangiferaIndica L.) J Chromatogr A. 2004;1054:261–8.
11. Knödler M, Berardini N, Kammerer DR, Carle R, Schieber A. Characterization of major and minor
alk(en)ylresorcinols from mango (MangiferaIndica L.) peels by high-performance liquid
chromatography/atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass
Spectrom. 2007;21:945–51.
12. Ornelas-Paz Jde J, Yahia EM, Gardea-Bejar A. Identification and quantification of xanthophyll esters,
carotenes, and tocopherols in the fruit of seven Mexican mango cultivars by liquid chromatographyatmospheric pressure chemical ionization-time-of-flight mass spectrometry [LC-(APcI(+))-MS] J Agric
Food Chem. 2007;55:6628–35.
13. Subha R, Pandey MM, Singh AK. A new, convenient method for determination of mangiferin: An antidiabetic compound, in MangiferaIndica L. J Planar Chromatogr. 2007;20:317–320.
14. Muruganandan S, Gupta S, Kataria M, Lal J, Gupta PK. Mangiferin protects the streptozotocin-induced
oxidative damage to cardiac and renal tissues in rats. Toxicology. 2002;176:165–73.
15. Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, et al. Chemical
investigation of some Indian plants: Part II. Indian J Chem. 1966;4:457–549.
16. Subbarayan C, Cama HR. Isolation & characterization of a carotenoid-protein complex
from Mangiferaindica(mango) Indian J Biochem. 1966;3:225–7. [PubMed]
17. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants
and reactive oxygen species. J NutrBiochem. 2007;18:567–79. [PubMed]
18. Diplock AT, Charleux JL, Crozier-Willi G, Kok FJ, Rice-Evans C, Roberfroid M, et al. Functional food
science and defense against reactive oxidative species. Br J Nutr. 1998;80:S77–112. [PubMed]
19. Maxwell SR. Anti oxidant therapy: Does it have a role in the treatment of human disease? Expert
OpinInvestig Drug. 1997;6:211–36. [PubMed]
20. Martinez G, Delgado R, Perez G, Garrido G, Nunez Selles AJ, Leon OS. Evaluation of the invitroantioxidant activity of Mangiferaindica L: Extract (Vimang) Phytother Res. 2000;14:424–
7. [PubMed]
21. Pardo-Andreu GL, Sanchez-Baldoquín C, Avila-González R, Yamamoto ET, Revilla A, Uyemura SA, et al. Interaction of Vimang (Mangiferaindica L.extract) with Fe(III) improves its antioxidant and cytoprotecting activity. Pharmacol Res. 2006;54:389–95. [PubMed]
22. Rocha Ribeiro SM, Queiroz JH, Lopes Ribeiro ME, Campos FM, Pinheiro Santana HM. Antioxidant in
mango (Mangiferaindica L.) pulp. Plant Foods Hum Nutr. 2007;62:13–7. [PubMed]
23. Gabino G, Deyarina G, Cheyla R, Nunez-Selles AJ, Rene D. Scavenger effect of a mango (MangiferaindicaL.) food supplement's active ingredient on free radicals produced by human polymorphonuclear cells and hypoxanthine–xanthine oxidase chemiluminescence systems. Food Chem. 2008; 107:1008–14.
24. Pardo Andreu G, Delgado R, Velho J, Inada NM, Curti C, Vercesi AE. MangiferaIndica L.extract (Vimang) inhibits Fe2+- citrate-induced lipoperoxidation in isolated rat liver mitochondria. Pharmacol Res. 2005; 51:427–35. [PubMed]
25. Sanchez GM, Re L, Giuliani A, Nuñez-Selles AJ, Davison GP, Leon-Fernandez OS. Protective effects of Mangiferaindica L.extract, mangiferin and selected antioxydants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol Res. 2000;42:565–73. [PubMed]
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