ASSOCIATION BETWEEN GINGIVAL ENLARGEMENT AND ANTI HYPERTENSIVE DRUGS- A RETROSPECTIVE STUD
DOI:
https://doi.org/10.61841/xk1qyb38Keywords:
Amlodipine, Cardiovascular, Drug, Enlargement, Gingiva, HypertensiveAbstract
Hypertension is also termed as high blood pressure. It can lead to severe health issues thereby increasing the risk of cardiovascular disease, stroke, culminating in death. The force that an individual’s blood is exerted against the ventricular and arterial walls of blood vessels is termed as blood pressure. This pressure is elicited based on the resistance of the blood vessels and how much of the cardiac output is. There are various methods to cope with hypertension such as diet modification, exercise, meditation and medication The aim of the study is to determine the association between gingival enlargement and anti hypertensive drugs.. A very common adverse effect of these drugs is gingival enlargement in the oral cavity. The enlargement of the gums caused due to anti-hypertensive drugs commences, due to their reactions in patients treated with anticonvulsants, immunosuppressants and calcium channel blockers. The data collected from the records were 86000 and they were screened for patients with drug induced gingival enlargement. The collected data was tabulated in excel sheet and imported to spss software for statistical analysis. From the study, 45 patients were diagnosed with drug induced gingival enlargement out of which, 24 patients were males and 21 patients were females. Predominant gender is male. Among the age groups, group 1[20-30 years] had 6 patients, group 2[36-50 years] had 16 patients and group 3[51-70 years] had 23 patients. The predominant age group was group 3[51- 70 years]. Among the type of drug used, gingival enlargement, amlodipine induced gingival enlargement was seen in 78%, nifedipine induced gingival enlargement was seen in 13%. Therefore, to conclude, the predominant drug induced gingival enlargement, was amlodipine in this study and the predominant age group was group 3 [51-70 years].
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1. Hallmon WW, Rossmann JA. The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concepts [Internet]. Vol. 21, Periodontology 2000. 1999. p. 176–96. Available from: http://dx.doi.org/10.1111/j.1600-0757.1999.tb00175.x
2. Dhale R, Phadnaik M. Conservative management of amlodipine influenced gingival enlargement [Internet]. Vol. 13, Journal of Indian Society of Periodontology. 2009. p. 41. Available from: http://dx.doi.org/10.4103/0972-124x.51894
3. Doufexi A, Mina M, Ioannidou E. Gingival overgrowth in children: Epidemiology, pathogenesis, and complications. A literature review. J Periodontol. 2005; 76:3–10.[3]
4. Wentz LA, Oliveira SC, Moreira CHC, Rösing CK. Low prevalence of gingival overgrowth associated with new immunosuppressive protocols with cyclosporin [Internet]. Vol. 26, Brazilian Oral Research 2011. p. 64–70. Available from: http://dx.doi.org/10.1590/s1806-83242011005000016
5. Greenberg KV, Armitage GC, Shiboski CH. Gingival Enlargement Among Renal Transplant Recipients in the Era of New-Generation Immunosuppressants [Internet]. Vol. 79, Journal of Periodontology. 2008. p. 453–60. Available from: http://dx.doi.org/10.1902/jop.2008.070434
6. Ramesh A, Varghese SS, Doraiswamy JN, Malaiappan S. Herbs as an antioxidant arsenal for periodontal diseases. J Intercult Ethnopharmacol. 2016 Jan;5[1]:92–6.
7. Priyanka S, Kaarthikeyan G, Nadathur JD, Mohanraj A, Kavarthapu A. Detection of cytomegalovirus, Epstein-Barr virus, and Torque Teno virus in subgingival and atheromatous plaques of cardiac patients with chronic periodontitis. J Indian Soc Periodontol. 2017 Nov;21[6]:456–60.
8. Panda S, Jayakumar ND, Sankari M, Varghese SS, Kumar DS. Platelet rich fibrin and xenograft in treatment of intrabony defect. Contemp Clin Dent. 2014 Oct;5[4]:550–4.
9. Thamaraiselvan M, Elavarasu S, Thangakumaran S, Gadagi J, Arthie T. Comparative clinical evaluation of coronally advanced flap with or without platelet rich fibrin membrane in the treatment of isolated gingival recession [Internet]. Vol. 19, Journal of Indian Society of Periodontology. 2015. p. 66. Available from: http://dx.doi.org/10.4103/0972-124x.145790
10. Ravi S, Malaiappan S, Varghese S, Jayakumar ND, Prakasam G. Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients with Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial [Internet]. Vol. 88, Journal of Periodontology. 2017. p. 839–45. Available from: http://dx.doi.org/10.1902/jop.2017.160824
11. Avinash K, Malaippan S, Dooraiswamy JN. Methods of Isolation and Characterization of Stem Cells from Different Regions of Oral Cavity Using Markers: A Systematic Review [Internet]. Vol. 10, International Journal of Stem Cells. 2017. p. 12–20. Available from: http://dx.doi.org/10.15283/ijsc17010
12. Ramesh A, Vellayappan R, Ravi S, Gurumoorthy K. Esthetic lip repositioning: A cosmetic approach for correction of gummy smile – A case series [Internet]. Vol. 23, Journal of Indian Society of
Periodontology. 2019. p. 290. Available from: http://dx.doi.org/10.4103/jisp.jisp_548_18
13. Marshall RI, Bartold PM. Medication induced gingival overgrowth [Internet]. Vol. 4, Oral Diseases. 2008. p. 130–51. Available from: http://dx.doi.org/10.1111/j.1601-0825.1998.tb00269.x
14. Varghese SS, Thomas H, Jayakumar ND, Sankari M, Lakshmanan R. Estimation of salivary tumor necrosis factor-alpha in chronic and aggressive periodontitis patients. Contemp Clin Dent. 2015 Sep;6[Suppl 1]:S152–6.
15. Khalid W. Comparison of Serum Levels of Endothelin-1 in Chronic Periodontitis Patients Before and After Treatment [Internet]. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. 2017. Available from: http://dx.doi.org/10.7860/jcdr/2017/24518.9698
16. Kavarthapu A, Thamaraiselvan M. Assessing the variation in course and position of inferior alveolar nerve among south Indian population: A cone beam computed tomographic study. Indian J Dent Res. 2018 Jul;29[4]:405–9.
17. Ramesh A, Ravi S, Kaarthikeyan G. Comprehensive rehabilitation using dental implants in generalized aggressive periodontitis [Internet]. Vol. 21, Journal of Indian Society of Periodontology. 2017. p. 160. Available from: http://dx.doi.org/10.4103/jisp.jisp_213_17
18. Ramamurthy, J., and V. Mg. Comparison of effect of Hiora mouthwash versus Chlorhexidine mouthwash in gingivitis patients: A clinical trial, Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no.7, July 2018, pp. 84-88.
19. Mootha A, Malaiappan S, Jayakumar ND, Varghese SS, Thomas JT. The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review [Internet]. Vol. 2016, International Journal of Inflammation. 2016. p. 1–8. Available from: http://dx.doi.org/10.1155/2016/3507503
20. Khalid W, Vargheese SS, Lakshmanan R, Sankari M, Jayakumar ND. Role of endothelin-1 in periodontal diseases: A structured review. Indian J Dent Res. 2016 May;27[3]:323–33.
21. Ramesh, A., Varghese, S.S., Jayakumar, N.D., Malaiappan, S.2016.Chronic obstructive pulmonary disease and periodontitis - Unwinding their linking mechanisms. Journal of Oral Biosciences. 58[1], 23-26.
22. Fay AA, Satheesh K, Gapski R. Felodipine-Influenced Gingival Enlargement in an Uncontrolled Type 2 Diabetic Patient [Internet]. Vol. 76, Journal of Periodontology. 2005. p. 1217. Available from: http://dx.doi.org/10.1902/jop.2005.76.7.1217
23. Ikawa K, Ikawa M, Shimauchi H, Iwakura M, Sakamoto S. Treatment of Gingival Overgrowth Induced by Manidipine Administration. A Case Report [Internet]. Vol. 73, Journal of Periodontology. 2002. p. 115–22. Available from: http://dx.doi.org/10.1902/jop.2002.73.1.115
24. Lafzi A, Farahani RMZ, Shoja MAM. Phenobarbital-induced Gingival Hyperplasia [Internet]. Vol. 8, The Journal of Contemporary Dental Practice. 2007. p. 50–6. Available from: http://dx.doi.org/10.5005/jcdp-8-6-50
25. Madi M, Shetty SR, Babu SG, Achalli S. Amlodipine Induced Gingival Hyperplasia – a Case Report and Review [Internet]. West Indian Medical Journal. 2015. Available from:
http://dx.doi.org/10.7727/wimj.2014.089
26. Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug-induced gingival overgrowth [Internet]. Vol. 33, Journal of Clinical Periodontology. 2006. p. 434–9. Available from: http://dx.doi.org/10.1111/j.1600-051x.2006.00930.x
27. Dhale RP, Phadnaik MB.2009. Conservative management of amlodipine influenced gingival enlargement. J Indian Soc Periodontol. 13:41–3.[2,25]
28. Pradhan S, Mishra P. Gingival Enlargement in Antihypertensive Medication [Internet]. Vol. 48, Journal of Nepal Medical Association. 2009. p. 149–52. Available from: http://dx.doi.org/10.31729/jnma.232
27. Aghanashini DS, D. A. P. M. R V Dental College Bangalore, India. Amlodipine Induced Gingival Overgrowth and its Nonsurgical Management– A Case Report [Internet]. Vol. 7, journal of Medical Science And clinical Research. 2019. Available from: http://dx.doi.org/10.18535/jmscr/v7i3.79
29. Jayanthi R, Mohammed Khalifa A, Archana, Sindhiya Jayachandran, Flaucy Varghese. 2017. Prevalence and severity of amlodipine induced gingival overgrowth. International Journal of Contemporary Medical Research. 4[2]:377-379. [27]
30. Sailendranath Biswas, Anindita Saha, Ashish Kumar Das;, 2017. Anti-hypertensive drug induced gingival enlargement- A case report, JODAGH, 10[1]: 7-11.[28] Available from:
http://dx.doi.org/10.4103/jorr.jorr_19_18
31. Seymour RA, Ellis JS, Thomason JM, Monkman S, Idle JR. Amlodipine-induced gingival overgrowth [Internet]. Vol. 21, Journal of Clinical Periodontology. 1994. p. 281–3. Available from: http://dx.doi.org/10.1111/j.1600-051x.1994.tb00318.x
32. Lederman D, Lumerman H, Reuben S, Freedman PD. Gingival hyperplasia associated with nifedipine therapy [Internet]. Vol. 57, Oral Surgery, Oral Medicine, Oral Pathology. 1984. p. 620–2. Available from: http://dx.doi.org/10.1016/0030-4220 [84]90283-4
33. Jorgensen MG. Prevalence of Amlodipine-Related Gingival Hyperplasia [Internet]. Vol. 68, Journal of Periodontology. 1997. p. 676–8. Available from: http://dx.doi.org/10.1902/jop.1997.68.7.676
34. Kantarci A, Nseir Z, Kim Y-S, Sume SS, Trackman PC. Loss of Basement Membrane Integrity in Human Gingival Overgrowth [Internet]. Vol. 90, Journal of Dental Research. 2011. p. 887–93. Available from: http://dx.doi.org/10.1177/0022034511404703
35. Subramani T, Rathnavelu V, Yeap SK, Alitheen NB. Influence of Mast Cells in Drug-Induced Gingival Overgrowth [Internet]. Vol. 2013, Mediators of Inflammation. 2013. p. 1–8. Available from: http://dx.doi.org/10.1155/2013/275172
35. Farhat Yaasmeen Sadique Basha, Rajeshkumar S, Lakshmi T, Anti-inflammatory activity of Myristica fragrans extract. Int. J. Res. Pharm. Sci., 2019 ;10(4), 3118-3120 DOI:
https://doi.org/10.26452/ijrps.v10i4.1607
36. Kaur G, Verhamme KMC, Dieleman JP, Vanrolleghem A, Van Soest EM, Ch. Stricker BH, et al. Association between calcium channel blockers and gingival hyperplasia [Internet]. Vol. 37, Journal of Clinical Periodontology. 2010. p. 625–30. Available from: http://dx.doi.org/10.1111/j.1600-051x.2010.01574.x
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