ASSOCIATION OF NEUTROPHIL LYMPHOCYTE RATIO WITH SEVERITY AND OUTCOME OF ACUTE ISCHEMIC STROKE PATIENTS
DOI:
https://doi.org/10.61841/g4yddt56Keywords:
Association, Neutrophil Lymphocyte Ratio,, Outcome, Acute Ischemic StrokeAbstract
ABSTRACT--The cumulative incidence of stroke ranged from 105 to 152/100,000 persons per year, and the crude prevalence of stroke ranged from 44.29 to 559/100,000 persons in different parts of the country during the past decade. Stroke is the second leading cause of death worldwide and mostly presents acutely. Among the strokes, ischemic stroke accounts for approximately 80% to 85% of the cases, and is characterized by the disruption of cerebral blood. Acute ischemic stroke is an inflammatory event where the ischemic tissues release chemokines and cytokines, and recruit peripheral circulating leukocytes. Among the leucocytes, neutrophils were found to be an important mediator and early neutrophilia was found to be associated with larger stroke volumes and poor prognosis lymphocytes also infiltrate the ischemic tissues and mediate inflammatory responses neutrophil- lymphocyte ratio as an inflammatory marker has been shown to be associated with poor prognosis in patients with malignancies and acute coronary syndrome.
Downloads
References
1. Kamalakannan S, Gudlavalleti ASV, Gudlavalleti VSM, Goenka S, Kuper H. Incidence & prevalence of stroke in India: A systematic review. Indian J Med Res. 2017 Aug;146(2):175–85.
2. Junior Resident, Department of General Medicine, KIMS Hospital, Bangalore, India, Lavanya DN. Relationship between Neutrophil Lymphocyte Ratio and Prognosis in Acute Ischemic Stroke. J Med Sci Clin Res [Internet]. 2018 Nov 26 [cited 2019 Aug 9];6(11). Available from: http://jmscr.igmpublication.org/v6-i11/113%20jmscr.pdf
3. Pandian JD, Sudhan P. Stroke Epidemiology and Stroke Care Services in India. J Stroke. 2013 Sep;15(3):128.
4. Maestrini I, Strbian D, Gautier S, Haapaniemi E, Moulin S, Sairanen T, et al. Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes. Neurology. 2015 Oct 20;85(16):1408– 16.
5. Petrone AB, Eisenman RD, Steele KN, Mosmiller LT, Urhie O, Zdilla MJ. Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2019 May 8;
6. Świtońska M, Słomka A, Korbal P, Piekuś-Słomka N, Sinkiewicz W, Sokal P, et al. Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Treatment Modalities of Acute Ischaemic Stroke: A Pilot Study. Medicina (Mex). 2019 Jul;55(7):342.
7. Kocaturk O, Besli F, Gungoren F, Kocaturk M, Tanriverdi Z. The relationship among neutrophil to lymphocyte ratio, stroke territory, and 3-month mortality in patients with acute ischemic stroke. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2019 Jan;40(1):139–46.
8. Zang J. Prognostic role of neutrophil-lymphocyte ratio in patients with acute ischemic stroke.
9. Ilaria M. Higher meutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes.
10. Xue J, Huang W, Chen X, Li Q, Cai Z, Yu T, et al. Neutrophil-to-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis Off J Natl Stroke Assoc. 2017 Mar;26(3):650– 7.
11. Zhang J, He M, Liu Z, Song Y, Wang Y, Liang R, et al. Impact of neutrophil–lymphocyte ratio on long- term outcome in patients with craniopharyngioma. Medicine (Baltimore) [Internet]. 2018 Sep 14 [cited 2019 Aug 9];97(37). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156074/
12. Zhu W, Leys D, Guo Z, Yu S, Maestrini I, Moulin S, et al. Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomesAuthor Response. Neurology. 2016 Mar 15;86(11):1077– 1077.
13. Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to Lymphocyte Ratio Predicts Poor Prognosis in Ischemic Cerebrovascular Disease. J Clin Lab Anal. 2014;28(1):27–31.
14. Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage. Stroke. 2016;47(6):1654–7.
15. Forget P, Khalifa C, Defour J-P, Latinne D, Van Pel M-C, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes. 2017 Jan 3;10(1):12.
16. Brott T, Marler JR, Olinger CP, Adams HP, Tomsick T, Barsan WG, et al. Measurements of acute cerebral infarction: lesion size by computed tomography. Stroke. 1989 Jul;20(7):871–5.
17. Papalkar, P., S. Kumar, S. Agrawal, N. Raisinghani, G. Marfani, and A. Mishra. “Heterotaxy Syndrome Presenting as Severe Pulmonary Artery Hypertension in a Young Old Female: Case Report.” Journal of Gerontology and Geriatrics 66, no. 2 (2018): 59–61.
18. Charan, N., M. Choudhari, M. Sonkusale, and R. Deshpande. “Anesthetic Management of Chronic Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 4 (2017): 289–91. https://doi.org/10.4103/jdmimsu.jdmimsu_40_17.
19. Gaikwad, K.B., N.G. Joshi, and S.P. Selkar. “Study of Nitrosative Stress in ‘Pregnancy Induced Hypertension.’” Journal of Clinical and Diagnostic Research 11, no. 3 (2017): BC06–8. https://doi.org/10.7860/JCDR/2017/23960.9396.
20. Yadav, S., M. Agrawal, C. Hariharan, D. Dewani, K. Vadera, and N. Krishna. “A Comparative Study of Serum Lipid Profile of Women with Preeclampsia and Normotensive Pregnancy.” Journal of Datta Meghe Institute of Medical Sciences University 13, no. 2 (2018): 83–86. https://doi.org/10.4103/jdmimsu.jdmimsu_70_17
21. Kumar, S., P. Bhayani, D. Hathi, and J. Bhagwati. “Hyponatremia Initial Presenting Feature of Normal Pressure Hydrocephalus in Elderly Patient: A Rare Case Report.” Journal of Gerontology and Geriatrics 66, no. 3 (2018): 156–57.
22. Bhinder, H.H.P.S., and T.K. Kamble. “The Study of Carotid Intima-Media Thickness in Prediabetes and Its Correlation with Cardiovascular Risk Factors.” Journal of Datta Meghe Institute of Medical Sciences University 13, no. 2 (2018): 79–82. https://doi.org/10.4103/jdmimsu.jdmimsu_58_18.
23. Khatib, M.N., R. Kirubakaran, S. Gaidhane, A.H. Shankar, and Z. Quazi Syed. “Yoga for Improving Functional Capacity, Quality of Life and Cardiovascular Outcomes in People with Heart Failure.” Cochrane Database of Systematic Reviews 2017, no. 7 (2017). https://doi.org/10.1002/14651858.CD012015.pub2.
24. Cladius, S., U. Jadhav, B. Ghewade, S. Ali, and T. Dhamgaye. “Study of Diabetes Mellitus in Association with Tuberculosis.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 2 (2017): 143–47. https://doi.org/10.4103/jdmimsu.jdmimsu_62_17.
25. Bhinder, H.H.P.S., and T.K. Kamble. “The Study of Carotid Intima-Media Thickness in Prediabetes and Its Correlation with Cardiovascular Risk Factors.” Journal of Datta Meghe Institute of Medical Sciences University 13, no. 2 (2018): 79–82. https://doi.org/10.4103/jdmimsu.jdmimsu_58_18.
26. Rathi, N., B. Taksande, and S. Kumar. “Nerve Conduction Studies of Peripheral Motor and Sensory Nerves in the Subjects with Prediabetes.” Journal of Endocrinology and Metabolism 9, no. 5 (2019): 147–
50. https://doi.org/10.14740/jem602.
27. Walinjkar, R.S., S. Khadse, S. Kumar, S. Bawankule, and S. Acharya. “Platelet Indices as a Predictor of Microvascular Complications in Type 2 Diabetes.” Indian Journal of Endocrinology and Metabolism 23, no. 2 (2019): 206–10. https://doi.org/10.4103/ijem.IJEM-13-19.
28. Phadnis, P., M.A. Kamble, S. Daigavane, P. Tidke, and S. Gautam. “Prevalence and Risk Factors – Hemoglobin A1c, Serum Magnesium, Lipids, and Microalbuminuria for Diabetic Retinopathy: A Rural Hospital-Based Study.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 2 (2017): 121–32. https://doi.org/10.4103/jdmimsu.jdmimsu_59_17.
29. Dande, R., A.R. Gadbail, S. Sarode, M.P.M. Gadbail, S.M. Gondivkar, M. Gawande, S.C. Sarode, G.S. Sarode, and S. Patil. “Oral Manifestations in Diabetic and Nondiabetic Chronic Renal Failure Patients Receiving Hemodialysis.” Journal of Contemporary Dental Practice 19, no. 4 (2018): 398–403. https://doi.org/10.5005/jp-journals-10024-2273.
30. Jagati, A., R. Chaudhary, S. Rathod, B. Madke, K. Baxi, and D. Kasundra. “Preparation of Platelet-Rich Fibrin Membrane over Scaffold of Collagen Sheet, Its Advantages over Compression Method: A Novel and Simple Technique.” Journal of Cutaneous and Aesthetic Surgery 12, no. 3 (2019): 174–78. https://doi.org/10.4103/2543-1854.267617
31. Swarnkar, M., and A. Agrawal. “Kimura’s Disease.” Formosan Journal of Surgery 51, no. 1 (2018): 26–
28. https://doi.org/10.4103/fjs.fjs_56_17.
32. Swarnkar, M., and P. Pandey. “Heterotopic Subserosal Pancreatic Tissue in Jejunum.” Formosan Journal of Surgery 51, no. 4 (2018): 167–70.
33. “Evaluation of Abdominal Malignancies by Minimal Access Surgery: Our Experience in a Rural Setup in Central India.” World Journal of Laparoscopic Surgery 11, no. 3 (2018): 115–20. https://doi.org/10.5005/jp-journals-10033-1350.
34. Yeola, M.E., D. Gode, and A.K. Bora. “Diagnostic Laparoscopy as an Effective Tool in Evaluation of Intra-Abdominal Malignancies.” World Journal of Laparoscopic Surgery 11, no. 2 (2018): 68–75. https://doi.org/10.5005/jp-journals-10033-1338.
35. Kirnake, V., A. Arora, P. Sharma, M. Goyal, R. Chawlani, J. Toshniwal, and A. Kumar. “Non-Invasive Aspartate Aminotransferase to Platelet Ratio Index Correlates Well with Invasive Hepatic Venous Pressure Gradient in Cirrhosis.” Indian Journal of Gastroenterology 37, no. 4 (2018): 335–41. https://doi.org/10.1007/s12664-018-0879-0.
36. Modi, L., S.R. Gedam, I.A. Shivji, V. Babar, and P.S. Patil. “Comparison of Total Self-Stigma between Schizophrenia and Alcohol Dependence Patients.” International Journal of High Risk Behaviors and Addiction 7, no. 3 (2018). https://doi.org/10.5812/ijhrba.61043.
37. Priya, N., Y.R. Lamture, and L. Luthra. “A Comparative Study of Scalpel versus Surgical Diathermy Skin Incisions in Clean and Clean-Contaminated Effective Abdominal Surgeries in AVBRH, Wardha, Maharashtra, India.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 1 (2017): 21–25. https://doi.org/10.4103/jdmimsu.jdmimsu_15_17.
38. Gaidhane, A., A. Sinha, M. Khatib, P. Simkhada, P. Behere, D. Saxena, B. Unnikrishnan, M. Khatib, M. Ahmed, and Q.S. Zahiruddin. “A Systematic Review on Effect of Electronic Media on Diet, Exercise, and Sexual Activity among Adolescents.” Indian Journal of Community Medicine 43, no. 5 (2018): S56–65. https://doi.org/10.4103/ijcm.IJCM_143_18.
39. Khatib, M.N., A.H. Shankar, R. Kirubakaran, A. Gaidhane, S. Gaidhane, P. Simkhada, and S.Z. Quazi. “Ghrelin for the Management of Cachexia Associated with Cancer.” Cochrane Database of Systematic Reviews 2018, no. 2 (2018). https://doi.org/10.1002/14651858.CD012229.pub2.
40. Agarwal, N.K., and S. Trivedi. “The Partial Pressure of Oxygen in Arterial Blood: A Relation with Different Fraction of Inspired Oxygen and Atmospheric Pressures.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 4 (2017): 280–83. https://doi.org/10.4103/jdmimsu.jdmimsu_31_18.
41. Ali, S., B. Ghewade, U. Jadhav, and S. Cladius. “Study of Serum Interferon Gamma in Tubercular Pleural Effusions.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 2 (2017): 93–98. https://doi.org/10.4103/jdmimsu.jdmimsu_53_17.
42. Alka, H.H., Z.R. Prajakta, C.S. Minal, G.N. Madhuri, P. Swati, and A. Aakruti. “Immunohistochemical Analysis of Tumor-Associated Stroma in Oral Squamous Cell Carcinoma with and without Preexisting Oral Submucous Fibrosis.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 3 (2017): 170–76. https://doi.org/10.4103/jdmimsu.jdmimsu_8_17.
43. Alloh, F.T., and P.R. Regmi. “Effect of Economic and Security Challenges on the Nigerian Health Sector.” African Health Sciences 17, no. 2 (2017): 591–92. https://doi.org/10.4314/ahs.v17i2.37.
44. Bains, S.K., P. John, D. Nair, S. Acharya, S. Shukla, and N. Acharya. “Aptitude of Medical Research in Undergraduate Students of a Medical University - Miles to Go before We Sow.” Journal of Clinical and Diagnostic Research 11, no. 12 (2017): JC07-JC11. https://doi.org/10.7860/JCDR/2017/29318.10972.
45. Baliga, M. “Scientific Appraisal, Evidence, Publication Points... Are Journals the Imperative Answer?” Journal of Indian Society of Pedodontics and Preventive Dentistry 35, no. 1 (2017): 1. https://doi.org/10.4103/0970-4388.199234.
46. Baliga, S. “Obituarty.” Journal of the Indian Society of Pedodontics and Preventive Dentistry 35, no. 3 (2017): 282. https://doi.org/10.4103/JISPPD.JISPPD_217_17.
47. Baliga, S., M. Chaudhary, S. Bhat, P. Bhatiya, N. Thosar, and P. Bhansali. “Determination of Toral Antioxidant Capacity of Saliva in Sickle Cell Anemic Patients - A Cross-Sectional Study.” Journal of Indian Society of Pedodontics and Preventive Dentistry 35, no. 1 (2017): 14–18. https://doi.org/10.4103/0970-4388.199219.
48. Basakhetre, U., A. Jaiswal, S. Deolia, S. Sen, M. Dawngliani, and A. Jaiswal. “Prevelance of Tobacco Use among School Children Reporting to Dental Hospital for Treatment.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 4 (2017): 242–45. https://doi.org/10.4103/jdmimsu.jdmimsu_28_18.
49. Behere, P.B., K. Kumar, and A.P. Behere. “Depression: Why to Talk?” Indian Journal of Medical Research 145, no. April (2017): 411–13. https://doi.org/10.4103/ijmr.IJMR_295_17.
50. Behere, P.B., H.D. Mansharamani, and K. Kumar. “Telepsychiatry: Reaching the Unreached.” Indian Journal of Medical Research 146, no. August (2017): 150–52. https://doi.org/10.4103/ijmr.IJMR_993_17.
51. Belekar, V. “A Comparative Study to Evaluate the Efficacy of Butorphanol as an Adjuvant to Epidural Analgesia for Rib Fractures.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 3 (2017): 166–69. https://doi.org/10.4103/jdmimsu.jdmimsu_105_17.
52. Bhalerao, N.S., A. Modak, and V. Belekar. “Comparison between Magnesium Sulfate (50 Mg/Kg) and Lignocaine (2 Mg/Kg) for Attenuation of Intubation Response in Hypertensive Patients.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 2 (2017): 118–20. https://doi.org/10.4103/jdmimsu.jdmimsu_58_17.
53. Bhalerao, S.M., V.K. Lohe, R.R. Bhowate, S.C. Mohod, and S. Patel. “Plexiform Unicystic Ameloblastoma: A Rare Variant of Ameloblastoma.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 4 (2017): 284–88. https://doi.org/10.4103/jdmimsu.jdmimsu_30_18.
54. Bhattacharjee, J., S. Jogdand, S. Goswami, R. Shinde, and M.R. Padhye. “Evaluation of Analgesic Activity of Simvastatin and Atorvastatin in Wistar Rats: An Experimental Study.” National Journal of Physiology, Pharmacy and Pharmacology 7, no. 10 (2017): 1031–35. https://doi.org/10.5455/njppp.2017.7.0411710052017.
55. Bhriegu, R., M. Agrawal, and C. Hariharan. “Assessment of Maternal and Perinatal Outcome in Postdated Pregnancy.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 1 (2017): 35–40. https://doi.org/10.4103/jdmimsu.jdmimsu_20_17.
56. Choudhari, M.S., N. Charan, M.I. Sonkusale, and R.A. Deshpande. “Inadvertent Diversion of Inferior Vena Cava to Left Atrium after Repair of Atrial Septal Defect - Early Diagnosis and Correction of Error: Role of Intraoperative Transesophageal Echocardiography.” Annals of Cardiac Anaesthesia 20, no. 4 (2017): 481–82. https://doi.org/10.4103/aca.ACA_83_17.
57. Cladius, S., U. Jadhav, B. Ghewade, S. Ali, and T. Dhamgaye. “Study of Diabetes Mellitus in Association with Tuberculosis.” Journal of Datta Meghe Institute of Medical Sciences University 12, no. 2 (2017): 143–47. https://doi.org/10.4103/jdmimsu.jdmimsu_62_17.
58. Dangore-Khasbage, S. “Clinical Aspects of Oral Cancer: A Case Report Series.” Dental and Medical Problems 54, no. 1 (2017): 85–89. https://doi.org/10.17219/dmp/67499.
59. Dhamgaye, T.M., and D.S. Bhaskaran. “An Unusual Pulmonary Metastatic Manifestation of Gestational Choriocarcinoma: A Diagnostic Dilemma.” Lung India 34, no. 5 (2017): 490–91. https://doi.org/10.4103/lungindia.lungindia_77_14.
60. Dhote, V.S., N.R. Thosar, S.M. Baliga, P. Dharnadhikari, P. Bhatiya, and P. Fulzele. “Surgical Management of Large Radicular Cyst Associated with Mandibular Deciduous Molar Using Platelet-Rich Fibrin Augmentation: A Rare Case Report.” Contemporary Clinical Dentistry 8, no. 4 (2017): 647–49. https://doi.org/10.4103/ccd.ccd_370_17.
61. Fande, P.Z., S.K. Patil, A.R. Gadbail, D.D. Ghatage, A.H. Hande, M.N. Gawande, and M.S. Chaudhary. “Neurovascular Hamartoma of Face: An Unusual Clinical Presentation.” World Journal of Dentistry 8, no. 2 (2017): 151–54. https://doi.org/10.5005/jp-journals-10015-1429.
62. Gadbail, A.R., M. Chaudhary, M. Gawande, A. Hande, S. Sarode, S.A. Tekade, S. Korde, et al. “Oral Squamous Cell Carcinoma in the Background of Oral Submucous Fibrosis Is a Distinct Clinicopathological Entity with Better Prognosis.” Journal of Oral Pathology and Medicine 46, no. 6 (2017): 448–53. https://doi.org/10.1111/jop.12553.
63. Gadbail, A.R., M.S. Chaudhary, S.C. Sarode, M. Gawande, S. Korde, S.A. Tekade, S. Gondivkar, A. Hande, and R. Maladhari. “Ki67, CD105, and α-SMA Expressions Better Relate the Binary Oral Epithelial Dysplasia Grading System of World Health Organization.” Journal of Oral Pathology and Medicine 46, no. 10 (2017): 921–27. https://doi.org/10.1111/jop.12612.
64. Gade, S.A., S.N. Chari, and A. Chalak. “Use of Mini-CEX as a Teaching Learning Method in Physiology for Undergraduate Medical Students.” National Journal of Physiology, Pharmacy and Pharmacology 7, no. 5 (2017): 482–85. https://doi.org/10.5455/njppp.2017.7.1029720122016.
65. Gaikwad, K.B., N.G. Joshi, and S.P. Selkar. “Study of Nitrosative Stress in ‘Pregnancy Induced Hypertension.’” Journal of Clinical and Diagnostic Research 11, no. 3 (2017): BC06–8. https://doi.org/10.7860/JCDR/2017/23960.9396.
66. Gaikwad, R., R. Bhowate, P. Bajad, A.R. Gadbail, S. Gondivkar, S.C. Sarode, G.S. Sarode, and S. Patil. “Potential Predictor of Tobacco Cessation among Factory Workers: A Baseline Data of Worksite Tobacco Cessation Programs in the Central Part of India.” Journal of Contemporary Dental Practice 18, no. 11 (2017): 1071–77. https://doi.org/10.5005/jp-journals-10024-2178.
67. Garg, S., A. Chakravarti, R. Singh, N.R.R. Masthi, R.C. Goyal, G.R. Jammy, E. Ganguly, et al. “Dengue Serotype-Specific Seroprevalence among 5- to 10-Year-Old Children in India: A Community-Based Cross-Sectional Study.” International Journal of Infectious Diseases 54 (2017): 25–30. https://doi.org/10.1016/j.ijid.2016.10.030.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
