Synthesis, Characterization And Antimicrobial Screening Of Novel Fused Heterocyclic Compounds

Authors

  • Purav V. Talaviya Department of Chemistry, Shri Manilal Kadakia College of Commerce, Management, Science and Computer Studies. Author

DOI:

https://doi.org/10.61841/b784j131

Keywords:

Pyrrole, Pyrimidine, Fused heterocyclic compounds, Spectral studies and Antimicrobial activity

Abstract

The 2-(2-bromo-1-(naphthalen-2-yl)ethylidene)malononitrile (2) synthesised by the reaction between 1-(naphthalen-2- yl)ethanone (1) with malononitrile. The compound (2) on reaction with substituted amines (3a-f) gives 2-amino-4- (naphthalen-2-yl)-1-aryl-1H-pyrrole-3-carbonitrile (4a-f). A series of 2-methyl-5-(naphthalen-2-yl)-7-aryl-3H-pyrrolo [2,3-d] pyrimidin-4(7H)-one derivatives (5a-f), when 2-amino-4-(naphthalen-2-yl)-1-aryl-1H-pyrrole-3-carbonitrile (4a-f) react with Ac2O in presence of pyridine. Synthesized compounds were characterized by IR, mass (MS) and 1H NMR spectra as well as elemental analysis. They were also screened for their in vitro antibacterial activity against Gram positive bacteria (Bacillus Subtilis Staphylococcus aureus, Gram-negative bacteria (Kllebsiella promioe, E.coil).

 

 

Downloads

Download data is not yet available.

References

1. K.M. Pandya, B.P. Dave, A.H. Patel, R.J. Patel, J.T. Patel and P.S. Desai, Asian Journal of Green Chemistry, 4, 416-433(2020).

2. S. M. Ali, S. A. Kadhem, A. Jabar, K. Atia, and R. I. Al-bayti, Journal of Global Pharma Technology, 3026(1),123– 125 (2018).

3. B. Patil, and P. Saha, Journal of Saudi Chemical Society,17(3),307-313(2013).

4. R. Abraham, P. Prakash, K. Mahendran, M. Ramanathan, Microb. Pathog., 114,409-413 (2018).

5. T. Li, M. Chiou, Y. Li, and H.Bao,Chem.Sci.,13,5667-5673(2022).

6. S. Ahmad, O. Alam, M.J. Naim, M. Shaquiquzzaman, M.M. Alam and M. Iqbal, Eur. J.Med. Chem.,17,435,2018.

7. M. Nagao, Y. Sato, A. Yamauchi, Int. J. Genom. Med.,2,1–7(2014).

8. P.C. Sharma, S. Yadav, R. Pahwa, D. Kaushik, S. Jain, Med. Chem. Res., 20,648–655 (2011).

9. S. A. Kadhem, S. M. Ali, A. Jabar, K. Atia, R. H. Salih, and R. A.Abdulrazaq, J. Pharm. Sci. Res., 10(11), 2818– 2824, (2018).

10. C. Kurumurthy, P.S. Rao, B. Veera swamy, G. S. Kumar, B. Narsaiah, L. R. Velatooru, R. Pamanji, Eur J Med Chem,46,3462(2011).

11. S. Tiwari, A. K. Yadav, A. K. Mishra, E-J Chem,7,S85(2010).

12. Y. Wu, L. Ying-Wu, H. Wei-Min, Chinese Chemical Letters,31(12), 2999(2020).

13. N. Ali, A. Elkanzi, A.A. Ghoneim, H. Hrichi, Chemistry Journal of Moldova-General, Industrial and Ecological Chemistry,14(2),105-116(2019).

14. V. Panchal, H.H. Variya, G.R.P atel, International Journal of Applied Engineering Research,14(1),43- 50(2019)(Spl.).

15. B.P. Saha, Indian Journal of Chemistry,60B,1223-1229(2021).

16. K. Khokhani, T. Khatri, V. Ram, P. Patel, Chemistry & Biology Interface,3,192(2013).

17. A.L. Barry, The Antimicrobial Susceptibility Test: Principal and Practices,4th ed., edited by Illuslea and Feger, Philadelphia,180,(1976).

18. E. I. Nweze, P. K. Mukherjee, M. A. Ghannoum, J. Clin. Microbiology, 48 (10), 3750-3752,(2019).

19. F. Tümer, D. Ekinci, K. Zilbeyaz, Ü. Demir, Turkish J. Chem.,28(4),395-404(2004).

20. S.K. Elsaedany, M.A. Zein, E.M. Abedel Rehim and R.M. Keshk, Journal of Heterocyclic Chemistry,15(2),346- 351(2015).

Downloads

Published

30.06.2020

Issue

Vol. 24 No. 4 (2020): 24 (4) 2020

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Talaviya, P. V. (2020). Synthesis, Characterization And Antimicrobial Screening Of Novel Fused Heterocyclic Compounds. International Journal of Psychosocial Rehabilitation, 24(4), 31290-31294. https://doi.org/10.61841/b784j131