EVALUATING THE IMPACT OF VITAMIN C ON ORAL HEALTH- A RANDOMISED CONTROL TRIAL
DOI:
https://doi.org/10.61841/be3sqm61Keywords:
Enamel Erosion, Gingivitis, Periodontitis, Scurvy, Vitamin CAbstract
Background: Oral health is an integral part of overall health. Nutrition plays an important role in maintaining oral and hence general health. Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays an important role in maintaining periodontal and oral health. However, excessive intake of vitamin C leads to detrimental oral conditions such as enamel erosion. Hence a balanced intake according to RDA is important.
Objectives: The present clinical study was conducted to evaluate the positive as well as the negative aspects of vitamin C on oral health.
Methodology: 170 patients were randomly categorized into 2 groups: Group 1 (n=85), the group with normal serum vitamin C levels and a history of adequate intake according to the Average Requirement valueand Group 2 (n=85), the group with deficient vitamin C levels and inadequate intake. Evaluation of oral manifestations and their prevalence was recorded in both groups by a well-experienced oral medicine expert, and findings were recorded in terms of gingivitis, periodontitis, petechiae, paleness of oral mucosa, and dental erosion. Data collected was statistically evaluated.
Results: One way ANOVA showed a statistically significant difference between two groups, where group 2 had significantly more patients with gingivitis and periodontitis as compared to group 1, with mean values of 1.3529±0.5049 & 1.5882±1.208 in group 1 and 1.6118±0.6743 & 2.4353±2.1737 in group 2 for gingivitis and periodontitis, respectively. In Group I, 27 subjects reported enamel erosion, 29 presented with bleeding gums, and 4 had established periodontitis. A petechial on buccal mucosa was seen in 1 patient, while 2 presented with pale mucosa. In Group II, enamel erosion was present in 4 subjects, bleeding gums/gingivitis in 50.5% of individuals, periodontitis in 17 cases, petechiae on the hard palate in 2, and petechiae on the buccal mucosa in 4.
Conclusion: Vitamin C (ascorbic acid) is an important vitamin that plays a key role in the maintenance of oral health and works as an antioxidant (free radical scavenger). Deficiency leads oral health detriment oral characterized by delayed wound healing, bleeding, swollen gingiva Pale mucosa was observed 12. However, the intergroup difference between two groups was statistically insignificant (p > 0.1). There was increased incidence and development of periodontal disease eventually leading to tooth loss. Adequate and balanced intake of vitamin C is advocated for a healthy oral cavity.
Downloads
References
[1] Beaudette JR, Fritz PC, Sullivan PJ, Ward WE. Oral Health, Nutritional Choices, and Dental Fear and Anxiety. Dent J (Basel). 2017;5:8.
[2] Michaud D.S., Kelsey K.T., Papathanasiou E., Genco C.A., Giovannucci E. Periodontal disease and risk of all cancers among male never smokers: An updated analysis of the Health Professionals Follow-up Study. Ann. Oncol. 2016;27:941–7.
[3] Priya Bahal and Serpil Djemal. Dental Erosion from an Excess of Vitamin C. Case Reports in Dentistry 2014. Article ID 485387 | 5 pages.
[4] Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P. Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem. 2013;28:314–28.
[5] Haworth WN, Hirst EL. Synthesis of ascorbic acid. J Soc Chem Ind (Lond) 1933;52:645–647.
[6] K. Akhilender Naidu. Vitamin C in human health and disease is still a mystery. An overview. Nutrition Journal 2003, 2:7.
[7] Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care 2002; 5: 66-74
[8] Akio Tada and Hiroko Miura. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int. J. Environ. Res. Public Health 2019;16:2472.
[9] Lykkesfeldt J, Michels AJ, Frei B. Vitamin C. Adv Nutr. 2014;5:16–8.
[10] Frei B, Birlouez I, Lykkesfeldt J. What is the optimum intake of vitamin C in humans? Crit Rev Food Sci Nutr. 2012;52:815–29
[11] Jung-Hoo Lee, Myung-Seop Shin, Eun-Jeong Kim, Yoo-Been Ahn, Hyun-Duck Kim. The association of dietary vitamin C intake with periodontitis among Korean adults: Results from KNHANES IV. PLoS ONE 2017;12:e0177074.
[12] Hada Divya, Garg Subhash, Khetarpal Shaleen, Ratre Madhu. Management of gingival enlargement by medical
& non-surgical dental therapy in a cerebral palsy patient—a case report. International Journal of
Periodontology and Implantology 2018;3:75-9.
[13] S. M. Blacker and R. G. Chadwick, “An in vitro investigation of the erosive potential of smoothies,” The
British Dental Journal 2013; 241:9.
[14] Loe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand 1963; 21:533-51.
[15] Russell AL. The Periodontal Index. J Periodontol. 1967;38:585–91.
[16] Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000.
[17] Baiju RM, Peter E, Varghese NO, Sivaram R. Oral Health and Quality of Life: Current Concepts. J Clin Diagn Res. 2017;11:21–6.
[18] Ghosh, Abhishek & SK, Pallavi & Nagpal, Dr. Bhuvan & Hegde, Usha & S, Archana & Nagpal, Jyoti. Role of Vitamins in Oral Health & Disease: An Overview. Indian Journal of Applied Research. 2015; 5: 292-5.
[19] Stegeman CA and Davis JR. The Dental Hygienist's Guide to Nutritional Care. 4th Edition. Elsevier Publication; 2014.
[20] Paula J. Moynihan. The role of diet and nutrition in the etiology and prevention of oral diseases. Bulletin of the World Health Organization. 2005;83:694-9.
[21] Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nutr J. 2003 Aug 21; 2: 7.
[22] Tada, A.; Miura, H. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int. J. Environ. Res. Public Health 2019, 16, 2472.
[23] Raghavendra U, Rao A, Kashyap SR, D'Souza J, Kumar V, Kalal BS, D'Souza N. Vitamin C supplementation as an adjunct to nonsurgical therapy in the treatment of chronic periodontitis: A clinical and biochemical study. J Int Oral Health 2018;10:256-61.
[24] Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingström P, Campus G. The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020;17:938.
[25] Najeeb, S.; Zafar, M.; Khurshid, Z.; Zohaib, S.; Almas, K. The Role of Nutrition in Periodontal Health: An Update. Nutrients 2016;8:530.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 AUTHOR

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.