Effect of Polygoni Multifori Radix Extract on Menopause-Related Skin Aging
DOI:
https://doi.org/10.61841/0ecyhp47Keywords:
Polygoni MultiflorI Radix, menopausal women, collagen, elastic fibers, anti-wrinkleAbstract
Background/Objectives: The purpose of this study was to prepare an emulsion containing Polygoni Multifori Radix extract to help improve aging of skin menopausal women.
Methods: The ovaries of 6–8-week-old SKH-1 hairless mouse were resected to induce menopausal aging, and Polygoni Multifori Radix extract were applied. This experimental group was compared with normal and natural aging controls.
Findings: Histological observations of the epidermis demonstrated that the average thickness of epidermal lipid lamellae was 11.1%, the proportion of epidermal lipid lamellae was 5.73%, and the overall epidermal thickness was increased in the menopausal aging group. The observation of histological changes in the dermis also showed increased density of collagen and decreased amount of denatured elastic fibers.
Improvements/Applications: Thus, Polygoni Multifori Radix extract was found to reduce the damage in skin tissues caused by menopausal aging and to suppress the wrinkles.
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[1] Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. The Journal of the American Medical Association. 1998 Oct;280(7):605-613.
[2] Liu J, Burdette JE, Xu H, Gu C, Breemen RV, Bhat KP, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Journal of agricultural and food chemistry. 2001 Sep;49(5);2472-2481.
[3] Mcconkey B, Fraser GM, Bligh AS, Whiteley H. Transparent skin and osteoporosis. Crossref. 1963 Mar;281(7283):693-695.
[4] Desmond JT. Introduction to skin aging. Journal of Tissue Viability. 2017 Jan;26(1):37-46.
[5] Kim MS. The Phytoestrogenic Effect of Daidzein in Human Dermal Fibroblasts. J Soc Cosmet Scientists Korea. 2014 Sep;40(3):279-287.
[6] Kim KH, Youn CK, Kim IJ, Lee KJ, Kim YH, Hong ST, et al. Morphological and Cytogenetic Analysis of Colchicine-induced Tetraploids of Fallopia multiflolra Haraldson. Korean J. Medicinal Crop Sci. 2018 Oct;26(5):362-369.
[7] Oh JS, Hong JH, Park TY, Yun KW, Kang KY, Jin SW, et al. Chemical Constituents in Polygonum multiflorum Thunberg Root Based on Various Dry Methods. Korean J Plant Res. 2018 Dec;31(4):283-293.
[8] Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005 Dec;11(4):221-235.
[9] Ghadially R, Brown BE, Sequeira SM, Feingold KR, Elias PM. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995 Oct;95(5):2281-2290.
[10] Scharffetter K, Brenneisen P, Wenk J, Herrmann G, Ma W, Kuhr L, et al. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 2000 Sep;35(3):307-316.
[11] Lee SJ, Kwon GT, Choi HR, Gim SW, Choi DH, Kong HS, et al. Establishment of the Male Menopause Animal Model Using Rats. Journal of Agriculture & Life Science. 2018 OCT;52(5):91-100.
[12] Gail J. Molecular mechanisms of skin ageing. Mechanisms of Ageing and Development. 2002 Oct;123(7):801–810.
[13] Fisher GJ, Choi HC, Bata CZ, Shao Y, Datta S, Wang ZQ, et al. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. J Invest Dermatol. 2001 Apr;117(2):219–226.
[14] Francis C, Robert L. Elastin and elastic fibres in normal and pathologic skin. Int J Dermatol. 1984 Mar;23(3):166–179.
[15] Kohen R, Gati I. Skin low molecular weight antioxidants and their role in aging and in oxidative stress. Toxicology. 2000 Sep;148(2):159–167.
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