A Study on the Physiological Activity of Stem Cell-Derived Conditioned Medium and Its Application for Cosmetic Materials

Authors

  • Ji-Sun Moon 1Professor, Dept. of Medical Beauty Care Jungwon University, 85 Munmu-ro, Goesan-eup, Goesan-gun, Chungbuk 28024, KOREA Author
  • Seon-hee You Professor, Dept. of Cosmetology, Dongnam Health University 50 Cheoncheon-ro, 74-Gil, Jangan-gu, Suwon-si, Gyonggi-do 16328, KOREA Author
  • Mi-Yun Yoon Professor, Dept. of Cosmetology, Dongnam Health University 50 Cheoncheon-ro, 74-Gil, Jangan-gu, Suwon-si, Gyonggi-do 16328, KOREA Author

DOI:

https://doi.org/10.61841/q6efrz34

Keywords:

Anti-aging,, Collagen, Cosmetic materials,, Physiological Activities, Stem Cell-derived Conditioned Medium

Abstract

Background: According to a study on the efficacy of fat derived stem cell culture on skin regeneration, an increase in collagen synthesis was observed when stem cell culture was applied to fibroblasts and keratinocytes. In this study, the authors tried to identify the anti-aging effect of fat derived stem cell cultures through intracellular mechanism of action on skin cells. Methods: In order to confirm the physiological activity potential of stem cell culture, skin cell activity test was performed to determine the toxicity, collagen production inhibitory activity, and MMP-1 expression. Findings: Cytotoxicity was not identified at all concentrations, it was confirmed that the collagen production increased by about 20% compared to the control group without the sample treatment, MMP-1 expression through JNK and ERK signaling pathway even at low concentration. Improvements: In this study suggest that fat-derived stem cell cultures are not toxic when used and may be useful as functional cosmetic materials with anti-aging effects.

 

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References

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Published

30.09.2020

Issue

Vol. 24 No. 7 (2020): 24 (7) 2020

Section

Articles

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How to Cite

Moon, J.-S., You, S.- hee, & Yoon, M.-Y. (2020). A Study on the Physiological Activity of Stem Cell-Derived Conditioned Medium and Its Application for Cosmetic Materials. International Journal of Psychosocial Rehabilitation, 24(7), 1905-1913. https://doi.org/10.61841/q6efrz34