The Anti-nociceptive activity of a herbo-mineral and Siddha Nano formulation Linga Chenduram (LC) in selective pain induced models in Swiss albino mice
DOI:
https://doi.org/10.61841/eh0fg178Keywords:
Linga chenduram, Anti-nociceptive activity, Siddha formulation, NanoAbstract
Background: The present study was aimed to investigate the anti-nociceptive activity of the Linga Chenduram in laboratory using the in vivo method so as to justify its traditional use in the above mentioned pathological conditions.
Methods: In vivo anti-nociceptive activity was performed employing the hot plate method, test on Swiss albino mice at doses of 3 and 6 mg/kg body weight. Finally, data were analyzed by one-way analysis of variance (ANOVA) and Dunnett’s t-test was used as the test of significance. P value < 0.001 was considered as the minimum level of significance. Results: Linga chenduram at dose of 3 mg/kg is statistically not significance when compared to Vehicle control group. At 6 mg/kg, the drug showed anti-nociceptive activity with significance (P<0.05) at 60mins and 90 mins when compared to the Vehicle control group.
Conclusions: The results obtained from the tests indicate that the Linga Chenduram having central and peripheral anti- nociceptive activity.
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References
1. Kandaswamy pillai. K, History of Siddha Medicine, Department of Indian Medicine and Homoeopathy, Chennai 600106, 2012, 2nd edition (Reprint), P – 1, 283-348.
2. Ramaswamy. R. S, Cancer research reviews in siddha system of medicine, central council for research in siddha, Ministry of AYUSH, Government of India, Arumbakkam, Tamil Nadu – 600106, 2015, P 5,17, 93.
3. Thirunarayanan T., Introduction to Siddha medicine, Centre for Traditional medicine and research, Adambakkam, Chennnai – 88, 2016, P - 47
4. Kingsley J. Standardization and Pharmacological Screening of Naaga Sangu Parpam (Doctoral dissertation, National Institute of Siddha, Chennai).
5. Uthamaraayan Ka. Su., Siddha Maruthuvanga Surukkam, Department of Indian medicine and homeopathy, 2018, P – 42,43
6. Hakkim Mohammad Abdullah Sahib, Anuboga vaithiya navanitham, Part - 4, 1995 October edition, P no. 57
7. Aruljothi R et al., Toxicity Study on Linga Chenduram, World Journal of Pharmacy and Pharmaceutical Sciences, Year 2018, Volume 7, Issue 12, Page 990-1002.
8. Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R. General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation. Int J Mol Sci. 2018 Jul 24;19(8):2164. doi: 10.3390/ijms19082164. PMID: 30042373; PMCID: PMC6121522
9. Gupta S. K, Drug Screening Methods, Jaypee Brothers, 3rdedition, 2016, P – 476 - 494.
10. Eddy N. B. & Leimbach D. Synthetic analgesics. II. Dithienylbutenyl and dithienylbutilamines. J Pharmacol Exp Ther. 1953; 107: 385–393.
11. Gupta S, George M, Singhal M, Sharma GN, Garg V. Leaves extract of murraya koenigii linn for anti-inflammatory and analgesic activity in animal models. J Adv Pharm Technol Res. 2010 Jan;1(1):68-77. PMID: 22247833; PMCID: PMC3255384
12. Kanagavalli K, Kavitha P, Anbu J, Rajeswaran PS, Parthiban P. Analgesic Activity of Sathikkai Podi - A Siddha Drug. International Journal of Pharmaceutical and Chemical Sciences. 2013 Apr;2(2).
13. Simpi CC, Nagathan CV, Karajgi SR, Kalyane NV. Evaluation of marine brown algae Sargassum ilicifolium extract for analgesic and anti-inflammatory activity. Pharmacognosy Research. 2013 Jul;5(3):146.
14. Basavraj, P., and M. Nitin. "Antinociceptive activity of Tulsi Amrit (A Polyherbal Formulation) in selective pain induced models in rats." Research Journal of Pharmacology and Pharmacodynamics 9.4 (2017): 173-17
15. Thanigavelan V, Lakshmanakumar V, Kaliyamurthi V, Kumar MP, Rajamanickam GV. Pharmacological study of a siddha holistic herb sivakaranthai-Sphaeranthus amaranthoides burm for analgesic and anti-inflammatory activities. Journal of Applied Pharmaceutical Science. 2012 Jan 30(Issue):95-101.
16. Howlader M, Islam S, Siraj M, Dey SK, Hira A, Ahmed A, Hossain M. Ficus hispida bark extract prevents nociception, inflammation, and CNS stimulation in experimental animal model. Evidence-Based Complementary and Alternative Medicine. 2017 Apr 12;2017.
17. Hossain H. Evaluation of antinociceptive and antioxidant activities of whole plant extract of Bacopa monniera. Research Journal of Medicinal Plant. 2012;6(8):607-14.
18. Mythilypriya R, Shanthi P, Sachdanandam P. Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation–Kalpaamruthaa. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Jun;21(6):574-8.
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