The effect of folic acid on lipid peroxidation in women with polycystic ovary syndrome
DOI:
https://doi.org/10.61841/bsck6t25Keywords:
folic acid, lipid peroxidation, polycystic ovary syndrome.Abstract
Introduction: Polycystic ovary syndrome (PCOS) is one of the important causes of infertility Worldwide and affects about 20% of infertile couples. Women with PCOS have a surged risk of first trimester spontaneous abortion ranging from 25% to 73%. Oxidative stress has been linked to various disorders; including epilepsy, depression, ulcerative colitis and other diseases. However, it is still unknown whether it is a cause or a consequence in PCOS.
Aim of the study: The aim of this study was to evaluate the effect of folic acid 5mg/daily on lipid peroxidation in adult females with polycystic ovary syndrome.
Methods: The current study was carried out on 120 women in reproductive period, their ages ranged from 18 to 39 years. They were organized into three groups: group one studied 40 women having a PCOS treated with 5mg/day folic acid/day for 3 months, group two included 40 adult females without PCOS treated with 5mg/day folic acid/day for 3 months, And group 3 included 40 females with PCOS not treated with 5mg/day folic acid/day.
Results: Folic acid administration at a daily dosage of 5 mg was found to reduce significantly the rate of lipid peroxidation byproduct, malondialdehyde (MDA) in PCOS women.
Conclusion: It was clear that folic acid supplementation to PCOS women in a given pharmacological dose might have a positive effect on oxidative stress.
Downloads
References
1. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745–2749.
2. Mahmood M, El-Basel M, Sheta M. Polycystic ovary syndrome in premenopausal women with type 2 diabetes mellitus: prevalence, characters and related morbidity. Med J Cairo Univ. 2009;77(4):327–335.
3. Legro RS. Polycystic ovary syndrome and cardiovascular disease: a premature association? Endocr Rev. 2003;24(3):302–312.
4. Hardiman P, Pillay OS, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003;361(9371):1810–1812.
5. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352(12): 1223–1236.
6. Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18(10):872– 879.
7. Essa MM, Braidy N, Waly MI, et al. Impaired antioxidant status and reduced energy metabolism in autistic children. Res Autism Spectr Disord. 2013;7(5):557–565.
8. Tapia-Vieyra JV, Delgado-Coello B, Mas-Oliva J. Atherosclerosis and cancer; a resemblance with far-reaching implications. Arch Med Res. 2017;48(1):12–26.
9. Tramutola A, Lanzillotta C, Perluigi M, Butterfield DA. Oxidative stress, protein modification and Alzheimer disease. Brain Res Bull. 2017; 133:88–96.
10. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress – a concise review. Saudi Pharm J. 2016;24(5):547–553.
11. Costa S, Reina-Couto M, Albino-Teixeira A, Sousa T. Statins and oxidative stress in chronic heart failure. Rev Port Cardiol. 2016;35(1): 41–57.
12. Tošić-Pajić J, Šeklić D, Radenković J, et al. Augmented oxidative stress in infertile women with persistent chlamydial infection. Reprod Biol. 2017;17(2):120–125.
13. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005; 3:28.
14. Bansal AK, Bilaspuri GS. Impacts of oxidative stress and antioxidants on semen functions. Vet Med Int. 2011; 2011:686137.
15. Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chem
Biol Interact. 2014; 224:164–175.
16. Novo E, Parola M. Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair. 2008;1(1):5.
17. Poston L, Igosheva N, Mistry HD, et al. Role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011;94(Suppl_6):1980S–1985S.
18. Hilali N, Vural M, Camuzcuoglu H, Camuzcuoglu A, Aksoy N. Increased prolidase activity and oxidative stress in PCOS. Clin Endocrinol (Oxf). 2013;79(1):105–110.
19. Papalou O, Victor VM, Diamanti-Kandarakis E. Oxidative stress in polycystic ovary syndrome. Curr Pharm Des. 2016;22(18):2709–2722.
20. Zhang R, Liu H, Bai H, et al. Oxidative stress status in Chinese women with different clinical phenotypes of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2017;86(1):88–96.
21. Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev. 2016; 2016:8589318.
22. Archibong AE, Rideout ML, Harris KJ, Ramesh A. Oxidative stress in reproductive toxicology. Curr Opin Toxicol. 2018; 7:95–101.
23. Yeon Lee J, Baw C-K, Gupta S, Aziz N, Agarwal A. Role of oxidative stress in polycystic ovary syndrome. Curr Womens Health Rev. 2010; 6(2):96–107.
24. Lefèvre G, Beljean-Leymarie M, Beyerle F, et al. Evaluation de la peroxydation lipidique par le dosage des substances réagissant avec l'acide thiobarbiturique [Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances]. Ann Biol Clin (Paris). 1998;56(3):305‐319.
25. Lorenz LB, Wild RA. Polycystic ovarian syndrome: an evidence-based approach to evaluation and management of diabetes and cardiovascular risks for today’s clinician. Clin Obstet Gynecol. 2007;50(1):226–243.
26. Halliwell, B. (2007) Biochemistry of oxidative stress: Figure 1. Biochem. Soc. Trans. 35, 1147–
1150.
27. Salim, S. (2014) Oxidative Stress and Psychological Disorders. Curr. Neuropharmacol. 12, 140–
147.
28. Ahamed, M., Fareed, M., Kumar, A., Siddiqui, W. A. and Siddiqui, M. K. J. (2008) Oxidative stress and neurological disorders in relation to blood lead levels in children. Redox Rep. 13, 117– 122.
29. M. Murri, M. Luque-ram´ırez, M. Insenser, M. Ojeda-ojeda, and H. F. Escobar-morreale, “Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis,” Human Reproduction Update, vol. 19, no. 3, Article ID dms059, pp. 268–288, 2013.
30. L. J. Moran, M. L. Misso, R. A. Wild, and R. J. Norman, “Impaired glucose tolerance, type 2
diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta- analysis,” Human Reproduction Update, vol. 16, no. 4, pp. 347–363, 2010.
31. Tas F, Hansel H, Belce A, Ilvan S, argon A, Camlica H, Topuz E (2005), “Oxidative stress in ovarian cancer”, Medical Oncology, 22(1), pp.11-15.
32. Yeh CC, Hou MF, Tsai SM, Lin SK, Hsiao JK, Huang JC, Wang LH, Wu SH, Hou LA, Ma H, Tsai LY (2005), “Superoxide anion radical, lipid peroxides and antioxidant status in the blood of patients with ovarian cancer”, Clinica Chimica Acta, Nov, 381(1-2), pp.104 –11.
33. Fatma Ferda Verit, Ozcan Erel (2008), Oxidative Stress in Nonobese Women with Polycystic Ovary Syndrome: Correlations with Endocrine and Screening Parameters, Gynecology Obstetrics Investigations, 65, 233-239.
34. Kuscu NK, Var A. Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2009; 88:612–7.
35. Zhang D, Luo W, Liao H, Wang C, Sun Y. The effects of oxidative stress to PCOS. Sichuan da xue xue bao. Yi xue ban= Journal of Sichuan University. Medical Science edition. 2008; 39:421– 3.
36. Palacio J, Iborra A, Ulcova-Gallova Z, Badia R, Martinez P. The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients. ClinExp Immunol. 2006; 144:217–22.
37. Sabuncu T, Vural H, Harma M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease. Clin Biochem. 2001; 34:407–13.
38. Fenkci V, Fenkci S, Yilmazer M, Serteser M. Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease. FertilSteril. 2003; 80:123–7.
39. Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): A systematic review and meta-analysis. Human Reprod Update. 2013; 19:268–88.
40. Mohamadin AM, Habib FA, Elahi TF. Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome. Pathophysiology. 2010;17(3):189–196.
41. Hilali N, Vural M, Camuzcuoglu H, Camuzcuoglu A, Aksoy N. Increased prolidase activity and oxidative stress in PCOS. Clin Endocrinol (Oxf). 2013;79(1):105–110.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
