Association between high-risk human papillomavirus infection female infertility

Authors

  • Sarab Khlalaf Hammood M.B.Ch.B. HD Ob. & Gyne. Kirkuk general hospital, Kirkuk health directorate- Iraq Author
  • Farah Majid Mohammed M.B.Ch.B. HD Ob. & Gyne. Al-Anbar health directorate- Iraq Author
  • Maysaloon Fadhil Hassan M.Sc. Medical Microbiology, Kirkuk general hospital, Kirkuk health directorate- Iraq Author

DOI:

https://doi.org/10.61841/2yhbsr17

Keywords:

HVP, High risk, Female infertility

Abstract

From a biological perspective, HPV is a very successful pathogen; that is, it can induce chronic infections without any systemic symptoms, allowing the host to periodically shed large amounts of transmissible virus to naïve individuals. A cross-sectional study was carried out in Kirkuk city-Iraq from June 2019 to the end of November 2019, including 200 women who attended to private clinics and suffering from infertility, and 100 controls (women without infertility). Five ml of blood was collected by vein puncture from each subject enrolled in this study. Blood samples were placed into sterile test tubes, the obtained sera were then aspirated using automatic micropipette and transferred into clean test tubes for detection of HPV16 and 18 E7 proteins by using ELISA technique. The study showed that the highest rate of HPV E7 proteins (29.5%) was detected in women with infertility comparing with healthy women (12%) with highly significant relation of HPV with infertility ( P. value: <0.05). The study stated that the highest rate of infertile women was infected with HPV 16 (37.29%) followed by HPV 58 (30.26%) while HPV 18 was found in 12.26% of those women and 13.56% of them was infected with both HPV 16 and HPV 58 genotypes. The highest mean of age were recorded among infertile women compared with healthy women (32.21 ± 6.68 v.s 31.80 ± 5.38 year) although the result was non- significant (P: > 0.05). The highest mean of BMI were recorded among non-infertile women compared with infertile women (23.92 ± 1.55 v.s 25.36±1.99 kg/m2), the result was significant. There was no significant difference regarding to LH, FSH, E2, progesterone level between infertile and control group women (p: < 0.05). It was concluded that female infertility was associated with HPV infection specially with HPV 16 and 18 serotypes.

 

Downloads

Download data is not yet available.

References

1. Souho T , Benlemlih M , Bennani B. Human papillomavirus infection and fertility alteration: A systematic review. PLoS ONE. 2015;10:e0126936.

2. Schiller JT , Lowy DR. Understanding and learning from the success of prophylactic human papillomavirus vaccines. Nat. Rev. Microbiol. 2012;10:681–692.

3. Datta J , Palmer MJ , Tanton C , Gibson LJ , Jones KG , Macdowall W , Glasier A , Sonnenberg P , Field N , Mercer CH , et al. Prevalence of infertility and help seeking among 15 000 women and men. Hum. Reprod. 2016;31:2108–2118.

4. Polis CB , Cox CM , Tunc McLain AC , Thoma ME. Estimating infertility prevalence in low-to-middle-income countries: An application of a current duration approach to Demographic and Health Survey data. Hum. Reprod. 2017;32:1064–1074.

5. Perino A , Giovannelli L , Schillaci R , Ruvolo G , Fiorentino FP , Alimondi P , Cefalù E , Ammatuna P. Human papillomavirus infection in couples undergoing in vitro fertilization procedures: Impact on reproductive outcomes. Fertil. Steril. 2011;95:1845–1848.

6. Spandorfer SD , Bongiovanni AM , Fasioulotis S , Rosenwaks Z , Ledger WJ , Witkin S S. Prevalence of cervical human papillomavirus in women undergoing in vitro fertilization and association with outcome. Fertil. Steril. 2006;86:765–767.

7. Zacharis K , Messini CI , Anifandis G , Koukoulis G , Satra M , Daponte A. Human papilloma virus (HPV) and fertilization: A mini review. Medicina. 2018;54:50.

8. Foresta C , Ferlin A , Bertoldo A , Patassini C , Zuccarello D , Garolla A. Human papilloma virus in the sperm cryobank: An emerging problem? Int. J. Androl. 2011;34:242–246.

9. Garolla A , Pizzol D , Bertoldo A , De Toni L , Barzon L , Foresta C. Association, prevalence, and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients. Fertil. Steril. 2013;99:125–131.

10. Foresta C , Noventa M , De Toni L , Gizzo S , Garolla A. HPV-DNA sperm infection and infertility: From a systematic literature review to a possible clinical management proposal. Andrology. 2015;3:163–173.

11. Çağlar GS , Garrido N. The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies. J. Turk. Ger. Gynecol. Assoc. 2018;19:48–52.

12. Calinisan JH , Chan SR , King A , Chan PJ. Human papillomavirus and blastocyst apoptosis. J. Assist. Reprod. Genet. 2002;19:132–136.

13. Hellberg D , Nilsson S. IVF and HPV. Fertil. Steril. 2007;87:1498.

14. Hermonat PL , Han L , Wendel PJ , Quirk JG , Stern S , Lowery CL , Rechtin TM. Human papillomavirus is more prevalent in first trimester spontaneously aborted products of conception compared to elective specimens. Virus Genes. 1997;14:13–17.

15. Moghimi M , Zabihi-Mahmoodabadi S , Kheirkhah-Vakilabad A , Kargar Z. Significant correlation between high- risk HPV DNA in semen and impairment of sperm quality in infertile men. Int. J. Fertil. Steril. 2019;12:306–309.

16. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. WHO; Geneva, Switzerland: 2010.

17. Laprise C , Trottier H , Monnier P , Coutlee F , Mayrand MH. Prevalence of human papillomaviruses in semen: A systematic review and meta-analysis. Hum. Reprod. 2014;29:640–651.

18. Yang Y , Jia CW , Ma YM , Zhou LY , Wang SY. Correlation between HPV sperm infection and male infertility. Asian J. Androl. 2013;15:529–532.

19. Elbashir S , Magdi Y , Rashed A , Ibrahim MA , Edris Y , Mostafa Abdelaziz A. Relationship between sperm progressive motility and DNA integrity in fertile and infertile men. Middle East Fertil. Soc. J. 2018;23:195–198.

20. N Muñoz, F Méndez, H Posso et al., “Incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of Colombian women with normal cytological results,” Journal of Infectious Diseases, 2004;190( 12): 2077–2087.

21. S Vaccarella, R Herrero, M Dai, et al., “Reproductive factors, oral contraceptive use, and human papillomavirus infection: pooled analysis of the IARC HPV prevalence surveys,” Cancer Epidemiology Biomarkers and Prevention, 200 ; 15( 11): 2148–2153

Downloads

Published

30.11.2020

Issue

Vol. 24 No. 9 (2020): 24 (9) 2020

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

How to Cite

Hammood, S. K., Mohammed, F. M., & Hassan, M. F. (2020). Association between high-risk human papillomavirus infection female infertility. International Journal of Psychosocial Rehabilitation, 24(9), 1952-1956. https://doi.org/10.61841/2yhbsr17