The study of the relationship of indicators of immune status and serum ferritin in patients with thalassemia.

Authors

  • U. U. Rakhmanova Basic doctoral student of the Department of Hematology, Transfusiology and Laboratory Affairs of the Tashkent Medical Academy. Uzbekistan Author
  • D.N. Suleymanova Doctor of medical sciences, professor, head of the anemia center of the Scientific Research Institute of Hematology and Blood Transfusion of the Republic of Uzbekistan Author
  • M.I. Shamsutdinova Doctor of medical sciences, associate professor of the Department of Hematology, Transfusiology and Laboratory Affairs of the Tashkent Medical Academy. Uzbekistan Author
  • I.Yu. Masharipova Hematologist, assistant of the department of faculty and hospital therapy of the Urgench branch of Tashkent Medical Academy. Author
  • N.H. Ishchanova Hematologist, assistant of the department of faculty and hospital therapy of the Urgench branch of Tashkent Medical Academy.Uzbekistan Author

DOI:

https://doi.org/10.61841/aa2mq652

Keywords:

hemosiderosis, hemolysis, humoral immunity, immunoglobulin, cellular immunity, ferritin

Abstract

Data on increased susceptibility to infections with thalassemia have generated interest in studying the immune status of patients with beta-thalassemia. The state of cellular and humoral immunity and the amount of iron-containing ferritin protein were studied in 200 patients, girls and boys with various forms of thalassemia. The indicators of humoral immunity, immunoglobulins A, M, G, as well as some indicators of cellular immunity CD3+, CD4+, CD8+, CD16+ were determined. Determination of immunoglobulins A, M, G was carried out by enzyme-linked immunosorbent assay on an apparatus of Human GmbH (Germany). Indicators of humoral immunity show a decrease in immunoglobulin A, but immunoglobulins M and G are elevated. Normally, ferritin is -10-120 ng / ml, and according to the results of our study, the content of serum ferritin is -1513.1 ng / ml, this indicator is 12.6 times higher, which indicates a risk of developing hemosiderosis of internal organs.

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References

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Published

30.11.2020

Issue

Vol. 24 No. 6 (2020): 24 (6) 2020

Section

Articles

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How to Cite

Rakhmanova, U. U., Suleymanova, D., Shamsutdinova, M., Masharipova, I., & Ishchanova, N. (2020). The study of the relationship of indicators of immune status and serum ferritin in patients with thalassemia. International Journal of Psychosocial Rehabilitation, 24(6), 423-426. https://doi.org/10.61841/aa2mq652