A CROSS-SECTIONAL COMPARISON OF MINERALS IN PSYCHIATRIC DISORDER
DOI:
https://doi.org/10.61841/v96g1f17Keywords:
Na, K, Ca, , Anxiety disorders,, , Panic disorders, Social phobia, Depression, , Bipolar disorders.Abstract
The burden of mental disorders with onset in childhood and adolescence decreased by varying degrees for the individual disorders, and this decrease was generally smaller in the less developed states than in the more developed states. The increase in the burden of depressive disorders, anxiety disorders, Panic disorders, Social phobia, and bipolar disorder was driven by the ageing of the population because age-standardisation nullified this increase. To study the levels of, sodium, potassium and calcium in psychiatric disorders.The present study includes total 100 subjects were selected for study. Out of which 50 were age and sex matched normal healthy control, 50 were suffered from psychiatric disorders. Blood sample were collected, and Electrolyte levels were measured by electrolyte analyzer, as electrolyte analyzer has different electrodes, specific for different ions of interest. Each electrode has an ion selective membrane that undergoes a specific reaction with the corresponding ions contained in the sample being analyzed.In our study the mean sodium levels in cases as 131.52±2.099 and in controls it was 137.98±6.06 (P<0.0001), this was statistically significant. Mean calcium and Potassium levels in cases were 13.30±3.35 and 3.35±0.23, while in controls it was 9.44±4.40 and 3.78±0.71 respectively. These results were also found to be statistically significant.The present study showed the levels of Na, K are decreased, and Ca concentration was increased found in psychiatric patients. Hyponatremia, hypokalemia, hypercalcaemia are clinical conditions which were present in patients of psychiatric disorders. Present study concludes that Careful evaluation of the patient will be helpful in Correction of underlying electrolyte abnormality which may improve the psychiatric symptoms and helpful for clinician for further treatment.
Downloads
References
1. Wakefield JC, Schmitz MF, First MB, Horwitz AV. Extending the bereavement exclusion for major depression to other losses: evidence from the National Comorbidity Survey. Arch Gen Psychiatry. 2007; 64:433–40.
2. Sachin Ratan Gedama, Imran Ali Shivji, Arvind Goyal, Lipsy Modi, Santanu Ghosh. Comparison of internet addiction, pattern and psychopathology between medical and dental students. Asian Journal of Psychiatry; Volume 22, August 2016, Pages 105-110.
3. Tejas V. Patel, Mehul J. Brahmbhatt, Ganpat K. Vankar. Prevalence of alcohol use disorders in hospitalised male patients. Archives of Psychiatry and Psychotherapy, 2018; 4: 47–55.
4. Manik Changoji Bhise and Prakash Balkrushna Behere. A case–control study of psychological distress in survivors of farmers' suicides in Wardha District in central India. Indian J Psychiatry. 2016 Apr-Jun; 58(2): 147–151.
5. Sutanaya Pal, Rajat M. Oswal, Ganpat K. Vankar. Recognition of major depressive disorder and its correlates among adult male patients in primary care. Archives of Psychiatry and Psychotherapy, 2018; 3: 55–62.
6. Hsu KJ, Young-Wolff KC, Kendler KS, Halberstadt LJ, Prescott CA. Neuropsychological deficits in major depression reflect genetic/familial risk more than clinical history: a monozygotic discordant twin-pair study. Psychiatry Res. 2014; 215:87–94.
7. Wilson S, Vaidyanathan U, Miller MB, McGue M, Iacono WG. Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course? Dev Psychopathol. 2014; 26:1477–93.
8. Institute of Health Metrics and Evaluation. GBD compare data visualisation. https://vizhub.healthdata.org/gbd-compare/ (accessed July 24, 2019).
9. Kyu HH, Abate D, Abate KH, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990- 2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1859–922.
10. Sarris J, Logan AC, Akbaraly TN, et al. International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry. 2015; 14:370–371.
11. Jacka FN, Pasco JA, Mykletun A, et al. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry. 2010; 167:305–311.
12. Shohag H, Ullah A, Qusar S, Rahman M, Hasnat A. Alterations of serum zinc, copper, manganese, iron, calcium, and magnesium concentrations and the complexity of interelement relations in patients with obsessive-compulsive disorder. Biol Trace Elem Res. 2012; 148:275–80.
13. Mustak MS, Rao TS, Shanmugavelu P, Sundar NM, Menon RB, Rao RV, et al. Assessment of serum macro and trace element homeostasis and the complexity of inter-element relations in bipolar mood disorders. Clin Chim Acta. 2008; 394:47–53.
14. Nahar Z, Azad MA, Rahman MA, Rahman MA, Bari W, Islam SN, et al. Comparative analysis of serum manganese, zinc, calcium, copper and magnesium level in panic disorder patients. Biol Trace Elem Res. 2010; 133:284–90.
15. Fukushima T, Tan X, Luo Y, Kanda H. Relationship between blood levels of heavy metals and Parkinson's disease in China. Neuroepidemiology. 2010; 34:18–24.
16. Błażewicz A, Liao KY, Liao HH, et al. Alterations of hair and nail content of selected trace elements in nonoccupationally exposed patients with chronic depression from different geographical regions. Biomed Res Int. 2017; 2017:3178784.
17. Jung KI, Ock SM, Chung JH, et al. Associations of serum Ca and Mg levels with mental health in adult women without psychiatric disorders. Biol Trace Elem Res. 2010; 133:153–61.
18. Leslie Baer, Stanley R. Platman, Ronald R. Fieve, The Role of Electrolytes in Affective Disorders Sodium, Potassium, and Lithium Ions. Arch Gen Psychiatry. 1970;22(2):108-113.
19. Shaw DM. Mineral metabolism, mania, and melancholia. Br Med J. 1966; 2:262:7.
20. Gitlin D: Hypokalemia and Hypomagnesemia, in Handbook of Medicine in Psychiatry. Edited by Manu P,Suarez RE,Barnett BJ. Washington, DC, American Psychiatric Publishing, 2006.
21. Mitchell W, Feldman F: Neuropsychiatric aspects of hypokalemia. Can Med Assoc J 1968; 98:49–51.
22. Mazzachi R D, Mazzachi B C, Berry M N: Sodium and potassium determination by enzyme activation. Eur. J. Clin. Chem. Clin. Biochem. Vol. 32, 1994:709-717
23. Thin C G, Thompson PA. Estimation of magnesium and urine by atomic absorption spectrophotometry. J Clin Pathol. 1967 May; 20(3): 280–282
24. Szkup M, Jurczak A, Brodowska A, et al. Analysis of relations between the level of mg, Zn, ca, cu, and Fe and depressiveness in postmenopausal women. Biol Trace Elem Res. 2017; 176:56–63.
25. Lam MH-B, Chau SW-H, Wing Y-K: High prevalence of hypokalemia in acute psychiatric inpatients. Gen Hosp Psychiatry 2009; 31:262–265.
26. Brown SW, Vyas BV, Spiegel DR. Mania in a case of hyperparathyroidism. Psychosomatics. 2007 May- Jun; 48(3):265-8.
27. Gitlin D: Hypokalemia and Hypomagnesemia, in Handbook of Medicine in Psychiatry. Edited by Manu P, Suarez RE, and Barnett BJ. Washington, DC, American Psychiatric Publishing, 2006
28. Mitchell W, Feldman F: Neuropsychiatric aspects of hypokalemia. Can Med Assoc J 1968; 98:49–51.
29. Dundas B, Harris M, Narasimhan M. Psychogenic polydipsia review: Etiology, differential and treatment. Current Psychiatry Reports (2007)9: 236-241.
30. Levinsky NG. Fluids and electrolytes. In: Isselbacher K, Braunwald E (eds.), Harrison’s Principles of Internal Medicine. McGraw-Hill, New York (1994).
31. Kumar S, Berl T Sodium. Lancet (1998); 352: 220-228.
32. Arieff AI, Llach F, Massry SG. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore) 1976; 55: 121-129.
33. Siegel AJ. Hyponatremia in psychiatric patients: update on evaluation and management. Harv Rev Psychiatry. 2008;16(1):13-24.
34. Lam MH-B, Chau SW-H, Wing Y-K: High prevalence of hypokalemia in acute psychiatric inpatients. Gen Hosp Psychiatry 2009; 31:262–265.
35. Ministry of Environment, Forest and Climate Change, Government of India. Regulation of lead contents in household and decorative paints rules 2016.
36. Ministry of Environment and Forests, Government of India. The batteries (management and handling) rules, 2001. 2001
37. Støving RK, Andries A, Brixen K, Bilenberg N, Hørder K. Gender differences in outcome of eating disorders: a retrospective cohort study. Psychiatry Res 2011; 186: 362–66.
38. Blodgett Salafia EH, Jones ME, Haugen EC, Schaefer MK. Perceptions of the causes of eating disorders: a comparison of individuals with and without eating disorders. J Eat Disord 2015; 3: 32-36.
39. Ravi Gupta, Sourav Das, Kishore Gujar, K K Mishra, Navendu Gaur, and Abdul Majid. Clinical Practice Guidelines for Sleep Disorders. Indian J Psychiatry. 2017 Jan; 59(Suppl 1): S116–S138.
40. Mathew, D. (2019). Yoga: An universal integrator and a potential tool for preventive health- an overview. International Journal of Advanced Science and Technology, 28(20), 861-864. Retrieved from www.scopus.com
41. Garg, A., & Negi, A. (2019). Multi operator based affine transformation function for fractal image generation with minimal distortion. International Journal of Advanced Science and Technology, 28(20), 1223-1238. Retrieved from www.scopus.com
42. Kingsly, A. A. S., & Mahil, J. (2019). Effective approach of learning based classifiers for skin cancer diagnosis from dermoscopy images. International Journal of Advanced Science and Technology, 28(20), 1016-1026. Retrieved from www.scopus.com
43. Sengupta, J., & Hemalatha, K. L. (2019). Automated inception network based cardiac image segmentation analysis. International Journal of Advanced Science and Technology, 28(20), 953-962. Retrieved from www.scopus.com
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.