Purpose of Intracellular Communication Connexin 43 in Breast Cancer Cells
DOI:
https://doi.org/10.61841/rkeymt06Keywords:
Tumor Microenvironment, Connexin 43,, Intracellular Communication, Cancer Stem Cells, Gap Junctions,, Cancer Dormancy.Abstract
Intracellular communication is a vital process that supports cellular activities in both normal breast cells and cancer embedded cells. The procedure is eased by gap junctions; a cluster of aqueous pathways that bond the interior of two neighboring cells. Gap junctions are composed of several connexins that sustain intracellular communication amid adjacent cells. The process entails an exchange of metabolites, ions and electric signals which support cell processes. The channels comprised of connexins support cell to cell association through diffusion. Unlike in normal breast cells, cancer cells have faults in gap junctions, caused by poorly expressed connexins. While there exists several types of connexins, connexin 43 is a special gap junction that functions independently and plays integral roles as far as intracellular communication amid cancerous cells is concerned. Such roles include gene transcription and signal transduction. As such, connexin 43 is associated with breast cancer pathogenesis. Based on the above findings, this paper highlights the major roles of gap junctions and connexin 43 intracellular communication, particularly in breast cancer development. Moreover, connexin 43 also enhances metastasis and invasion which are vital in cancer cell dormancy and regeneration of cancer stem cells. Therefore, the paper also features inclusive knowledge regarding functional dynamics and discrepancy expression of connexin 43 the pathogenesis of breast cancer.
Downloads
References
[1] Banerjee, D. (2016). Connexin’sConnection in Breast Cancer Growth and Progression. International Journal of cell biology, 2016.Retrieved from https://www.hindawi.com/journals/ijcb/2016/9025905/
[2] Bazzoun, D., Lelièvre, S., &Talhouk, R. (2015). Beyond the Channel: Role of Connexins in Regulating Normal and Cancerous Processes in the Mammary Gland. In Intercellular Communication in Cancer (pp. 1-28). Springer, Dordrecht. Retrieved from https://link.springer.com/chapter/10.1007/978-94-017-7380-5_1
[3] Beckmann, A., Hainz, N., Tschernig, T., & Meier, C. (2019). Facets of Communication: Gap Junction Ultrastructure and Function in Cancer Stem Cells and Tumor Cells. Cancers, 11(3), 288. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468480/
[4] Gava, F., Rigal, L., Mondesert, O., Pesce, E., Ducommun, B., &Lobjois, V. (2018). Gap Junctions Contribute To Anchorage-Independent Clustering Of Breast Cancer Cells. BMC Cancer, 18(1), 221.
Retrieved from https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4148-5
[5] Grek, C. L., Rhett, J. M., Bruce, J. S., Ghatnekar, G. S., &Yeh, E. S. (2016). Connexin 43, Breast Cancer Tumor Suppressor: Missed Connections?. Cancer letters, 374(1), 117-126. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S0304383516300623
[6] Phillips, S. L., Williams, C. B., Zambrano, J. N., Williams, C. J., &Yeh, E. S. (2017). Connexin43 In The Development And Progression Of Breast Cancer: What's The Connection?. International journal of oncology, 51(4), 1005-1013. Retrieved from https://www.spandidos-publications.com/ijo/51/4/1005
[7] Sinyuk, M., Mulkearns-Hubert, E. E., Reizes, O., &Lathia, J. (2018). Cancer Connectors: Connexins, Gap Junctions, and Communication. Frontiers in oncology, 8, 646. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308394/
[8] Stoletov, K., Strnadel, J., Zardouzian, E., Momiyama, M., Park, F. D., Kelber, J. A., ... &Klemke, R. L. (2013). Role of Connexins in Metastatic Breast Cancer and Melanoma Brain Colonization. J Cell Sci, 126(4), 904-913. Retrieved from https://jcs.biologists.org/content/126/4/904.short
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
