Synthesis, Characterization And Antibacterial Activity Of Azitidinone Containing Compounds

The Schiff’s bases, 4-(substituted benzylidene amino)-N-(5-methylisoxazol-3-yl) benzene sulfonamide (3a-f) were papered from Sulphamethoxazole (1) and aromatic aldehydes (2a-f), then it were condensed with chloro acetyl chloride to yields 2-azitidinone derivatives, namely 4-(3-chloro-2-oxo-4-arylazetidin-1-yl)-N-(5-methylisoxazol-3-yl) benzene sulfonamide (4a-f). The (4a-f) were further treated with 1H-imidazole to 4-(3-(1H-imidazol-1-yl)-2-oxo-4-arylazetidin-1-yl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide(6a-f). The derivatives (3a-f),(4a-f) and (6a-f) were characterized by elemental content and spectral features. Their antibacterial activity has also been monitored against common microbes.