COMMON RISK FACTORS ASSOCIATED WITH OSTEOPOROSIS AND TOOTH LOSS
DOI:
https://doi.org/10.61841/b26rt276Keywords:
Bone mineral density, estrogen, inflammation, osteoporosis, periodontitis, osteopenia, prostaglandinAbstract
Osteoporosis is a systemic skeletal disease characterized by low bone mass and bone tissue deterioration with a consequent increase in bone fragility and susceptibility to fracture. Low bone mineral density [BMD], age and low body mass index have been found to be major risk factors for osteoporosis. Periodontitis presents as a pathological loss of periodontal ligaments and alveolar bone resorption. The disease develops due to complex interactions between microbes and exaggerated immune response. Since both the diseases have a convergent mechanism leading to tissue destruction, investigation of the common markers would enable early diagnosis of the diseases. The aim of the present study was to identify these common inflammatory markers associated with osteoporosis and tooth loss by text-mining process. Furthermore, the brief review throws light on the underlying mechanisms behind the development of the disease, its management, treatment and prevention options. An extensive review of literature was carried to locate studies relating world-wide prevalence of osteoporosis and its association with tooth loss and other oral problems.
Downloads
References
1. 1.Ashwin KS, Muralidharan NP. Vancomycin-resistant enterococcus [VRE] vs Methicillin-resistant Staphylococcus Aureus [MRSA] [Internet]. Vol. 33, Indian Journal of Medical Microbiology. 2015. p. 166. Available from: http://dx.doi.org/10.4103/0255-0857.150976
2. Girija ASS, Smiline Girija AS, Vijayashree Priyadharsini J, Paramasivam A. Plasmid-encoded resistance to trimethoprim/sulfamethoxazole mediated by dfrA1, dfrA5, sul1 and sul2 among Acinetobacter baumannii isolated from urine samples of patients with severe urinary tract infection [Internet]. Vol. 17, Journal of Global Antimicrobial Resistance. 2019. p. 145–6. Available from: http://dx.doi.org/10.1016/j.jgar.2019.04.001
3. Sabarathinam J, Nallaswamy D, Nallaswamy D, Np M, Np M. Comparison of herbal mouthwash with commercially available 0.2% chlorhexidine and 2% betadine mouthwashes in patients after stage-1 implant surgery [Internet]. Vol. 10, Asian Journal of Pharmaceutical and Clinical Research. 2017. p. 56. Available from: http://dx.doi.org/10.22159/ajpcr.2017.v10i12.17786
4. Pratha AA, Ashwatha Pratha A, Geetha RV. Awareness on Hepatitis-B vaccination among dental students- A Questionnaire Survey [Internet]. Vol. 10, Research Journal of Pharmacy and Technology. 2017. p. 1360. Available from: http://dx.doi.org/10.5958/0974-360x.2017.00240.2
5. Vaishali M, Geetha RV. Antibacterial activity of Orange peel oil on Streptococcus mutans and Enterococcus-An In-vitro study [Internet]. Vol. 11, Research Journal of Pharmacy and Technology. 2018.
p. 513. Available from: http://dx.doi.org/10.5958/0974-360x.2018.00094.x
6. M MA, Geetha RV, Thangavelu L. Evaluation oEvaluation of anti-inflammatory action of Laurus nobilis- an in vitro study of anti-inflammatory action of Laurus nobilis-an in vitro study [Internet]. Vol. 10, International Journal of Research in Pharmaceutical Sciences. 2019. p. 1209–13. Available from: http://dx.doi.org/10.26452/ijrps.v10i2.408
7. Marickar RF, Geetha RV, Neelakantan P. Efficacy of Contemporary and Novel Intracanal Medicaments againstEnterococcus Faecalis [Internet]. Vol. 39, Journal of Clinical Pediatric Dentistry.2014.p.47– 50.Availablefrom:http://dx.doi.org/10.17796/jcpd.39.1.wmw9768314h5666
8. Shahana RY, Muralidharan NP. Efficacy of mouth rinse in maintaining oral health of patients attending orthodontic clinics [Internet]. Vol. 9, Research Journal of Pharmacy and Technology. 2016.p.1991.Availablefrom:http://dx.doi.org/10.5958/0974-360x.2016.00406.6
9. Girija SAS, Jayaseelan VP, Arumugam P. Prevalence of VIM- and GIM-producing Acinetobacter baumannii from patients with severe urinary tract infection [Internet]. Vol. 65, Acta Microbiologica et Immunologica Hungarica. 2018. p. 539–50. Available from: http://dx.doi.org/10.1556/030.65.2018.038
10. Monfared AM, Rezaei A, Poursina F, Faghri J. Detection of Genes Involved in Biofilm Formation in MDR and XDR Acinetobacter baumannii Isolated from Human Clinical Specimens in Isfahan, Iran [Internet]. Vol. In Press, Archives of Clinical Infectious Diseases. 2019. Available from: http://dx.doi.org/10.5812/archcid.85766
11. Smiline ASG, Vijayashree JP, Paramasivam A. Molecular characterization of plasmid-encoded blaTEM, blaSHV and blaCTX-M among extended spectrum β-lactamases [ESBLs] producing Acinetobacter baumannii [Internet]. Vol. 75, British Journal of Biomedical Science. 2018. p. 200–2. Available from: http://dx.doi.org/10.1080/09674845.2018.1492207
12. Paramasivam A, VijayashreePriyadharsini J, Raghunandhakumar S. N6-adenosine methylation [m6A]: a promising new molecular target in hypertension and cardiovascular diseases. Hypertens Res [Internet]. 2020Feb;43[2]:p153–4.Availablefrom:http://dx.doi.org/10.1038/s41440-019-0338-z
13. Priyadharsini JV, VijayashreePriyadharsini J, SmilineGirija AS, Paramasivam A. An insight into the emergence of Acinetobacter baumannii as an oro-dental pathogen and its drug resistance gene profile – An in-silico approach [Internet]. Vol. 4, Heliyon. 2018. p. e01051.Availablefrom:http://dx.doi.org/10.1016/j.heliyon.2018.e01051
14. SohaibShahzan M, SmilineGirija AS, VijayashreePriyadharsini J. A computational study targeting the mutated L321F of ERG11 gene in C. albicans, associated with fluconazole resistance with bioactive compounds from Acacianilotica. J Mycol Med [Internet]. 2019 Dec;29[4]p:303–9. Availablefrom:http://dx.doi.org/10.1016/j.mycmed.2019.100899
15. Silverman SL, Minshall ME, Shen W, Harper KD, Xie S, on behalf of the Health-Related Quality of Life Subgroup of the Multiple Outcomes of Raloxifene Evaluation Study. The relationship of health-related quality of life to prevalent and incident vertebral fractures in postmenopausal women with osteoporosis: Results from the Multiple Outcomes of Raloxifene Evaluation Study [Internet]. Vol. 44, Arthritis & Rheumatism. 2001. p. 2611–9. http://dx.doi.org/10.1002/1529-0131[200111]44.
16. Oleksik AM, Ewing S, Shen W, van Schoor NM, Lips P. Impact of incident vertebral fractures on health related quality of life [HRQOL] in postmenopausal women with prevalent vertebral fractures [Internet]. Vol. 16, Osteoporosis International. 2005. p. 861–70. Available from: http://dx.doi.org/10.1007/s00198- 004-1774-3
17. VijayashreePriyadharsini J. In silico validation of the non-antibiotic drugs acetaminophen and ibuprofen as antibacterial agents against red complex pathogens. J Periodontol [Internet]. 2019 Dec;90[12]:1441–8. Availablefrom:http://dx.doi.org/10.1002/JPER.18-0673
18. Girija As S, Priyadharsini J V. CLSI based antibiogram profile and the detection of MDR and XDR strains isolated from urine samples. Med J Islam Repub Iran [Internet]. 2019 Feb p8;33:3. Available from: http://dx.doi.org/10.34171/mjiri.33.3
19. Priyadharsini JV, Vijayashree Priyadharsini J, Smiline Girija AS, Paramasivam A. In silico analysis of virulence genes in an emerging dental pathogen A. baumannii and related species [Internet]. Vol. 94, Archives of Oral Biology.2018. p.93–8.Available from: http://dx.doi.org/10.1016/j.archoralbio.2018.07.001
20. Sivakumar S, Smiline Girija AS, Vijayashree Priyadharsini J. Evaluation of the inhibitory effect of caffeic acid and gallic acid on tetR and tetM efflux pumps mediating tetracycline resistance in Streptococcus sp., using computational approach [Internet]. Vol. 32, Journal of King Saud University - Science. 2020. p. 904–
9. Available from: http://dx.doi.org/10.1016/j.jksus.2019.05.003
21. Kepley AL, Nishiyama KK, Zhou B, Wang J, Zhang C, McMahon DJ, et al. Differences in bone quality and strength between Asian and Caucasian young men [Internet]. Vol. 28, Osteoporosis International. 2017. p. 549–58. Available from: http://dx.doi.org/10.1007/s00198-016-3762-9
22. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures [Internet]. Vol. 17, Osteoporosis International. 2006. p. 1726–33. Available from: http://dx.doi.org/10.1007/s00198-006-0172-4
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
